Names & Taxonomy
- Uniprot ID:
- P07550
- Entry Name:
- ADRB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
- Gene Names:
- ADRB2 ADRB2R B2AR
- Gene Names Primary:
- ADRB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 413
- Sequence:
- MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
- Cross Reference Drug Bank:
- DB01193 DB00866 DB00321 DB00182 DB01102 DB01274 DB06216 DB00335 DB01408 DB00195 DB00217 DB01295 DB00612 DB08807 DB08808 DB00248 DB00521 DB01136 DB04846 DB01407 DB01151 DB00449 DB00841 DB06262 DB01363 DB00668 DB01288 DB00983 DB05039 DB00221 DB01064 DB00598 DB01210 DB01365 DB01214 DB00264 DB00370 DB01203 DB04861 DB00368 DB00540 DB00334 DB09080 DB00816 DB01580 DB01359 DB00925 DB00397 DB00960 DB01291 DB01366 DB00571 DB00852 DB00867 DB01001 DB00938 DB00489 DB00871 DB00373 DB00726 DB09082
- Gene Ontology Go:
- apical plasma membrane
axon
caveola
dendritic spine
early endosome
endosome
integral component of plasma membrane
lysosome
neuronal cell body membrane
nucleus
plasma membrane
receptor complex
sarcolemma
beta2-adrenergic receptor activity
dopamine binding
drug binding
epinephrine binding
norepinephrine binding
potassium channel regulator activity
protein homodimerization activity
activation of adenylate cyclase activity
activation of transmembrane receptor protein tyrosine kinase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
associative learning
bone resorption
brown fat cell differentiation
cell surface receptor signaling pathway
cell-cell signaling
cellular response to hypoxia
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
diet induced thermogenesis
endosome to lysosome transport
estrous cycle
excitatory postsynaptic potential
female pregnancy
heat generation
liver regeneration
negative regulation of angiogenesis
negative regulation of inflammatory response
negative regulation of multicellular organism growth
negative regulation of ossification
negative regulation of platelet aggregation
negative regulation of smooth muscle contraction
negative regulation of urine volume
positive regulation of apoptotic process
positive regulation of ATPase activity
positive regulation of autophagosome maturation
positive regulation of bone mineralization
positive regulation of cell proliferation
positive regulation of lipophagy
positive regulation of MAPK cascade
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of potassium ion transport
positive regulation of protein ubiquitination
positive regulation of skeletal muscle tissue growth
positive regulation of sodium ion transport
positive regulation of the force of heart contraction by epinephrine
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vasodilation
receptor-mediated endocytosis
regulation of calcium ion transport
regulation of sensory perception of pain
response to cold
response to dexamethasone
response to estrogen
response to monoamine
response to progesterone
response to testosterone
synaptic transmission, glutamatergic
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
wound healing - Gene Ontology Biological Process:
- activation of adenylate cyclase activity
activation of transmembrane receptor protein tyrosine kinase activity
adenylate cyclase-activating adrenergic receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
associative learning
bone resorption
brown fat cell differentiation
cell-cell signaling
cell surface receptor signaling pathway
cellular response to hypoxia
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
diaphragm contraction
diet induced thermogenesis
endosome to lysosome transport
estrous cycle
excitatory postsynaptic potential
female pregnancy
heat generation
liver regeneration
negative regulation of angiogenesis
negative regulation of inflammatory response
negative regulation of multicellular organism growth
negative regulation of ossification
negative regulation of platelet aggregation
negative regulation of smooth muscle contraction
negative regulation of urine volume
positive regulation of apoptotic process
positive regulation of ATPase activity
positive regulation of autophagosome maturation
positive regulation of bone mineralization
positive regulation of cell proliferation
positive regulation of lipophagy
positive regulation of MAPK cascade
positive regulation of mitophagy in response to mitochondrial depolarization
positive regulation of potassium ion transport
positive regulation of protein ubiquitination
positive regulation of skeletal muscle tissue growth
positive regulation of sodium ion transport
positive regulation of the force of heart contraction by epinephrine
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vasodilation
receptor-mediated endocytosis
regulation of calcium ion transport
regulation of sensory perception of pain
response to cold
response to dexamethasone
response to estrogen
response to monoamine
response to progesterone
response to testosterone
synaptic transmission, glutamatergic
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
wound healing - Gene Ontology Molecular Function:
- beta2-adrenergic receptor activity
dopamine binding
drug binding
epinephrine binding
norepinephrine binding
potassium channel regulator activity
protein homodimerization activity - Gene Ontology Cellular Component:
- apical plasma membrane
axon
caveola
dendritic spine
early endosome
endosome
integral component of plasma membrane
lysosome
neuronal cell body membrane
nucleus
plasma membrane
receptor complex
sarcolemma - Keywords:
- 3D-structure
Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Hydroxylation
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Q5TCQ9; O14745; P12931