Names & Taxonomy
- Uniprot ID:
- P07510
- Entry Name:
- ACHG_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetylcholine receptor subunit gamma
- Gene Names:
- CHRNG ACHRG
- Gene Names Primary:
- CHRNG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Function
- Function:
- After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
- Cross Reference Drug Bank:
- DB00674
- Gene Ontology Go:
- acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane
acetylcholine receptor activity
acetylcholine-activated cation-selective channel activity
channel activity
cation transmembrane transport
chemical synaptic transmission, postsynaptic
muscle contraction
neuromuscular synaptic transmission
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Biological Process:
- cation transmembrane transport
chemical synaptic transmission, postsynaptic
muscle contraction
neuromuscular synaptic transmission
response to nicotine
signal transduction
synaptic transmission
synaptic transmission, cholinergic
transport - Gene Ontology Molecular Function:
- acetylcholine-activated cation-selective channel activity
acetylcholine receptor activity
channel activity - Gene Ontology Cellular Component:
- acetylcholine-gated channel complex
cell junction
integral component of plasma membrane
plasma membrane
postsynaptic membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Synapse
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q15323; P60409; P60410; P60411; Q7Z3S9