Names & Taxonomy
- Uniprot ID:
- P07202
- Entry Name:
- PERT_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyroid peroxidase (TPO) (EC 1.11.1.8)
- Gene Names:
- TPO
- Gene Names Primary:
- TPO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQRNLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFESCDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQLTCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVDSGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQAVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.; Isoform 3: Cell surface.
Function
- Function:
- Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
- Pathway:
- Hormone biosynthesis; thyroid hormone biosynthesis.
- Catalytic Activity:
- 2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.; -L-tyrosine + iodide + H(2)O(2) = -3-iodo-L-tyrosine + 2 H(2)O.; -3-iodo-L-tyrosine + iodide + H(2)O(2) = -3,5-diiodo-L-tyrosine + 2 H(2)O.; 2 -3,5-diiodo-L-tyrosine + H(2)O(2) = -L-thyroxine + -aminoacrylate + 2 H(2)O.; -3-iodo-L-tyrosine + -3,5-diiodo-L-tyrosine + H(2)O(2) = -3,5,3'-triiodo-L-thyronine + -aminoacrylate + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 239 239 Proton acceptor.
- Cross Reference Drug Bank:
- DB00389 DB00509 DB00763 DB00550
- Gene Ontology Go:
- cell surface
extracellular space
integral component of plasma membrane
mitochondrion
plasma membrane
calcium ion binding
heme binding
iodide peroxidase activity
peroxidase activity
cellular nitrogen compound metabolic process
cellular oxidant detoxification
cellular response to nitric oxide
embryonic hemopoiesis
hormone biosynthetic process
hydrogen peroxide catabolic process
response to lipid
small molecule metabolic process
thyroid hormone generation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cellular oxidant detoxification
cellular response to nitric oxide
embryonic hemopoiesis
hormone biosynthetic process
hydrogen peroxide catabolic process
response to lipid
small molecule metabolic process
thyroid hormone generation - Gene Ontology Molecular Function:
- calcium ion binding
heme binding
iodide peroxidase activity
peroxidase activity - Gene Ontology Cellular Component:
- cell surface
extracellular space
integral component of plasma membrane
mitochondrion
plasma membrane - Keywords:
- Alternative splicing
Calcium
Complete proteome
Congenital hypothyroidism
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Heme
Hydrogen peroxide
Iron
Membrane
Metal-binding
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Signal
Sushi
Thyroid hormones biosynthesis
Transmembrane
Transmembrane helix