Names & Taxonomy

Uniprot ID:
P06858
Entry Name:
LIPL_HUMAN
Status:
reviewed
Protein Names:
Lipoprotein lipase (LPL) (EC 3.1.1.34)
Gene Names:
LPL LIPD
Gene Names Primary:
LPL
Organism:
Homo sapiens (Human)

Structure

Length:
475
Sequence:
MESKALLVLTLAVWLQSLTASRGGVAAADQRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEVDIGELLMLKLKWKSDSYFSWSDWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQKGKAPAVFVKCHDKSLNKKSG
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).
Catalytic Activity:
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Active Site:
ACT_SITE 159 159 Nucleophile.; ACT_SITE 183 183 Charge relay system.; ACT_SITE 268 268 Charge relay system.
Cross Reference Drug Bank:
DB05269 DB06439
Gene Ontology Go:
anchored component of membrane
cell surface
chylomicron
extracellular exosome
extracellular matrix
extracellular region
extracellular space
plasma membrane
very-low-density lipoprotein particle
apolipoprotein binding
heparin binding
lipoprotein lipase activity
phospholipase activity
receptor binding
triglyceride binding
triglyceride lipase activity
cholesterol homeostasis
chylomicron remodeling
fat-soluble vitamin metabolic process
fatty acid biosynthetic process
lipoprotein metabolic process
phospholipid metabolic process
phototransduction, visible light
positive regulation of chemokine secretion
positive regulation of cholesterol storage
positive regulation of inflammatory response
positive regulation of macrophage derived foam cell differentiation
positive regulation of sequestering of triglyceride
response to cold
response to drug
response to glucose
retinoid metabolic process
small molecule metabolic process
triglyceride biosynthetic process
triglyceride catabolic process
triglyceride homeostasis
triglyceride metabolic process
very-low-density lipoprotein particle remodeling
vitamin metabolic process
Gene Ontology Biological Process:
cholesterol homeostasis
chylomicron remodeling
fat-soluble vitamin metabolic process
fatty acid biosynthetic process
lipoprotein metabolic process
phospholipid metabolic process
phototransduction, visible light
positive regulation of chemokine secretion
positive regulation of cholesterol storage
positive regulation of inflammatory response
positive regulation of macrophage derived foam cell differentiation
positive regulation of sequestering of triglyceride
response to cold
response to drug
response to glucose
retinoid metabolic process
small molecule metabolic process
triglyceride biosynthetic process
triglyceride catabolic process
triglyceride homeostasis
triglyceride metabolic process
very-low-density lipoprotein particle remodeling
vitamin metabolic process
Gene Ontology Molecular Function:
apolipoprotein binding
heparin binding
lipoprotein lipase activity
phospholipase activity
receptor binding
triglyceride binding
triglyceride lipase activity
Gene Ontology Cellular Component:
anchored component of membrane
cell surface
chylomicron
extracellular exosome
extracellular matrix
extracellular region
extracellular space
plasma membrane
very-low-density lipoprotein particle
Keywords:
Cell membrane
Chylomicron
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
GPI-anchor
Glycoprotein
Heparin-binding
Hydrolase
Hyperlipidemia
Lipid degradation
Lipid metabolism
Lipoprotein
Membrane
Nitration
Polymorphism
Reference proteome
Secreted
Signal
VLDL

Publication

PubMed ID:
3823907 2701938 2243796 1537564 14702039 15489334 1406652 2340307 11342582 17997385 18780401 8308035 2121025 1969408 1975597 2110364 1702428 1907278 2010533 1674945 1752947 2038366 1598907 1521525 1639392 1730727 1371284 1400331 1619366 1479292 8096693 8288243 8486765 8325986 8301230 8135797 7999071 7906986 7912254 8077845 7806969 7647785 8858123 8872057 8956048 8956052 8728326 8778602 9298816 9401010 9279761 9714430 9498099 10660334 9719626 9662394 10391209 11068186 11099402 11134145 10787434 11441134 12204001 12641539 12966036 14984478 15185149 15256764 15877202