Names & Taxonomy
- Uniprot ID:
- P06744
- Entry Name:
- G6PI_HUMAN
- Status:
- reviewed
- Protein Names:
- Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)
- Gene Names:
- GPI
- Gene Names Primary:
- GPI
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 558
- Sequence:
- MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMRGKSTEEARKELQAAGKSPEDLERLLPHKVFEGNRPTNSIVFTKLTPFMLGALVAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSAQVTSHDASTNGLINFIKQQREARVQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
- Pathway:
- Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
- Catalytic Activity:
- D-glucose 6-phosphate = D-fructose 6-phosphate.
- Active Site:
- ACT_SITE 358 358 Proton donor.; ACT_SITE 389 389; ACT_SITE 519 519
- Gene Ontology Go:
- ciliary membrane
cytoplasm
cytosol
extracellular exosome
extracellular space
membrane
myelin sheath
neuron projection
nucleoplasm
plasma membrane
glucose-6-phosphate isomerase activity
intramolecular transferase activity
monosaccharide binding
ubiquitin protein ligase binding
aldehyde catabolic process
angiogenesis
canonical glycolysis
carbohydrate metabolic process
erythrocyte homeostasis
gene expression
gluconeogenesis
glucose 6-phosphate metabolic process
glucose homeostasis
glucose metabolic process
hemostasis
humoral immune response
in utero embryonic development
learning or memory
mesoderm formation
methylglyoxal biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- aldehyde catabolic process
angiogenesis
canonical glycolysis
carbohydrate metabolic process
erythrocyte homeostasis
gene expression
gluconeogenesis
glucose 6-phosphate metabolic process
glucose homeostasis
glucose metabolic process
hemostasis
humoral immune response
in utero embryonic development
learning or memory
mesoderm formation
methylglyoxal biosynthetic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- glucose-6-phosphate isomerase activity
intramolecular transferase activity
monosaccharide binding
ubiquitin protein ligase binding - Gene Ontology Cellular Component:
- ciliary membrane
cytoplasm
cytosol
extracellular exosome
extracellular space
membrane
myelin sheath
neuron projection
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Angiogenesis
Complete proteome
Cytokine
Cytoplasm
Direct protein sequencing
Disease mutation
Gluconeogenesis
Glycolysis
Growth factor
Hereditary hemolytic anemia
Isomerase
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Ubl conjugation