Names & Taxonomy
- Uniprot ID:
- P06731
- Entry Name:
- CEAM5_HUMAN
- Status:
- reviewed
- Protein Names:
- Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e)
- Gene Names:
- CEACAM5 CEA
- Gene Names Primary:
- CEACAM5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 702
- Sequence:
- MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
- Gene Ontology Go:
- anchored component of membrane
basolateral plasma membrane
extracellular exosome
integral component of external side of plasma membrane
integral component of plasma membrane
GPI anchor binding
identical protein binding
protein homodimerization activity
homotypic cell-cell adhesion
negative regulation of anoikis
negative regulation of apoptotic process
negative regulation of myotube differentiation - Gene Ontology Biological Process:
- homotypic cell-cell adhesion
negative regulation of anoikis
negative regulation of apoptotic process
negative regulation of myotube differentiation - Gene Ontology Molecular Function:
- GPI anchor binding
identical protein binding
protein homodimerization activity - Gene Ontology Cellular Component:
- anchored component of membrane
basolateral plasma membrane
extracellular exosome
integral component of external side of plasma membrane
integral component of plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
GPI-anchor
Glycoprotein
Immunoglobulin domain
Lipoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Signal - Interacts With:
- Itself