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Names & Taxonomy

Uniprot ID:: P06241
Entry Name:: FYN_HUMAN
Status:: reviewed
Protein Names:: Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene Names:: FYN
Gene Names Primary:: FYN
Organism:: Homo sapiens (Human)

Structure

Length:: 537
Sequence:: MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm. Nucleus. Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

Function

Function:: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Catalytic Activity:: ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Cofactor:: COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
Enzyme Regulation:: ENZYME REGULATION: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
Active Site:: ACT_SITE 390 390 Proton acceptor.
Cross Reference Drug Bank:: DB01254
Gene Ontology Go:: actin filament
cytosol
endosome
extrinsic component of cytoplasmic side of plasma membrane
mitochondrion
nucleus
plasma membrane
postsynaptic density
ATP binding
ephrin receptor binding
glycoprotein binding
growth factor receptor binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
activated T cell proliferation
activation of MAPKK activity
adaptive immune response
axon guidance
blood coagulation
calcium ion transport
cell differentiation
cell migration
cellular response to platelet-derived growth factor stimulus
cellular response to transforming growth factor beta stimulus
dendrite morphogenesis
detection of mechanical stimulus involved in sensory perception of pain
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
feeding behavior
fibroblast growth factor receptor signaling pathway
forebrain development
innate immune response
insulin receptor signaling pathway
intracellular signal transduction
learning
leukocyte migration
MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of gene expression
negative regulation of neuron apoptotic process
negative regulation of protein catabolic process
negative regulation of protein ubiquitination
neuron migration
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein localization to nucleus
positive regulation of tyrosine phosphorylation of Stat5 protein
protein phosphorylation
Ras protein signal transduction
regulation of apoptotic process
regulation of cell proliferation
regulation of cell shape
regulation of defense response to virus by virus
response to drug
response to ethanol
small GTPase mediated signal transduction
stimulatory C-type lectin receptor signaling pathway
T cell activation
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Biological Process:: activated T cell proliferation
activation of MAPKK activity
adaptive immune response
axon guidance
blood coagulation
calcium ion transport
cell differentiation
cell migration
cellular response to platelet-derived growth factor stimulus
cellular response to transforming growth factor beta stimulus
dendrite morphogenesis
detection of mechanical stimulus involved in sensory perception of pain
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
feeding behavior
fibroblast growth factor receptor signaling pathway
forebrain development
innate immune response
insulin receptor signaling pathway
intracellular signal transduction
learning
leukocyte migration
MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of gene expression
negative regulation of neuron apoptotic process
negative regulation of protein catabolic process
negative regulation of protein ubiquitination
neuron migration
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine autophosphorylation
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of neuron projection development
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of protein localization to nucleus
positive regulation of tyrosine phosphorylation of Stat5 protein
protein phosphorylation
Ras protein signal transduction
regulation of apoptotic process
regulation of cell proliferation
regulation of cell shape
regulation of defense response to virus by virus
response to drug
response to ethanol
small GTPase mediated signal transduction
stimulatory C-type lectin receptor signaling pathway
T cell activation
T cell costimulation
T cell receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
vascular endothelial growth factor receptor signaling pathway
viral process
Gene Ontology Molecular Function:: ATP binding
ephrin receptor binding
glycoprotein binding
growth factor receptor binding
metal ion binding
non-membrane spanning protein tyrosine kinase activity
protein tyrosine kinase activity
Gene Ontology Cellular Component:: actin filament
cytosol
endosome
extrinsic component of cytoplasmic side of plasma membrane
mitochondrion
nucleus
plasma membrane
postsynaptic density
Keywords:: 3D-structure
ATP-binding
Adaptive immunity
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Host-virus interaction
Immunity
Kinase
Lipoprotein
Manganese
Membrane
Metal-binding
Myristate
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
SH2 domain
SH3 domain
Transferase
Tyrosine-protein kinase
Interacts With:: O92972; P27958; Q9WMX2; P42684; Q13444; A7KAX9; O14559; Q9ULH1; P56945; O43281; P04626; P48023; P02751-7; O15117; P31424-2; P08238; P50406; Q07666; Q92918; Q9H204; Q9NZQ3; Q8WX92; Q9NWQ8; Q8WUM4; P09619; O43900; Q05655; Q04759; Q13905; O60880; Q8BHK6; Q9Y2W2

Names & Taxonomy

Structure

Subcellular location

Function

Publication