Names & Taxonomy
- Uniprot ID:
- P06133
- Entry Name:
- UD2B4_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 2B4 (UDPGT 2B4) (EC 2.4.1.17) (HLUG25) (Hyodeoxycholic acid-specific UDPGT) (UDPGTh-1)
- Gene Names:
- UGT2B4 UGT2B11
- Gene Names Primary:
- UGT2B4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 528
- Sequence:
- MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome membrane
Function
- Function:
- UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB08907 DB00318 DB06292 DB00712 DB01050 DB00295
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
glucuronosyltransferase activity
cellular glucuronidation
estrogen catabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular glucuronidation
estrogen catabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix