Names & Taxonomy

Uniprot ID:
P06133
Entry Name:
UD2B4_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 2B4 (UDPGT 2B4) (EC 2.4.1.17) (HLUG25) (Hyodeoxycholic acid-specific UDPGT) (UDPGTh-1)
Gene Names:
UGT2B4 UGT2B11
Gene Names Primary:
UGT2B4
Organism:
Homo sapiens (Human)

Structure

Length:
528
Sequence:
MSMKWTSALLLIQLSCYFSSGSCGKVLVWPTEFSHWMNIKTILDELVQRGHEVTVLASSASISFDPNSPSTLKFEVYPVSLTKTEFEDIIKQLVKRWAELPKDTFWSYFSQVQEIMWTFNDILRKFCKDIVSNKKLMKKLQESRFDVVLADAVFPFGELLAELLKIPFVYSLRFSPGYAIEKHSGGLLFPPSYVPVVMSELSDQMTFIERVKNMIYVLYFEFWFQIFDMKKWDQFYSEVLGRPTTLSETMAKADIWLIRNYWDFQFPHPLLPNVEFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMVSNTSEERANVIASALAKIPQKVLWRFDGNKPDTLGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGVPLFADQPDNIAHMKAKGAAVSLDFHTMSSTDLLNALKTVINDPLYKENAMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVTGFLLACVATVIFIITKCLFCVWKFVRTGKKGKRD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Microsome membrane

Function

Function:
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Cross Reference Drug Bank:
DB08907 DB00318 DB06292 DB00712 DB01050 DB00295
Gene Ontology Go:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
glucuronosyltransferase activity
cellular glucuronidation
estrogen catabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular glucuronidation
estrogen catabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
glucuronosyltransferase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
3109396 8333863 10376768 14702039 15815621 15489334 19159218 24275569