Names & Taxonomy
- Uniprot ID:
- P05546
- Entry Name:
- HEP2_HUMAN
- Status:
- reviewed
- Protein Names:
- Heparin cofactor 2 (Heparin cofactor II) (HC-II) (Protease inhibitor leuserpin-2) (HLS2) (Serpin D1)
- Gene Names:
- SERPIND1 HCF2
- Gene Names Primary:
- SERPIND1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 499
- Sequence:
- MKHSLNALLIFLIITSAWGGSKGPLDQLEKGGETAQSADPQWEQLNNKNLSMPLLPADFHKENTVTNDWIPEGEEDDDYLDLEKIFSEDDDYIDIVDSLSVSPTDSDVSAGNILQLFHGKSRIQRLNILNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMKLTKGLIKDALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVGGISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKNGNMAGISDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVANPSRS
- Proteomes:
- UP000005640
Function
- Function:
- Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
- Cross Reference Drug Bank:
- DB00407 DB06271
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
endopeptidase inhibitor activity
heparin binding
serine-type endopeptidase inhibitor activity
bioluminescence
blood coagulation
chemotaxis
negative regulation of endopeptidase activity - Gene Ontology Biological Process:
- bioluminescence
blood coagulation
chemotaxis
negative regulation of endopeptidase activity - Gene Ontology Molecular Function:
- endopeptidase inhibitor activity
heparin binding
serine-type endopeptidase inhibitor activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Blood coagulation
Chemotaxis
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Hemostasis
Heparin-binding
Luminescence
Phosphoprotein
Photoprotein
Polymorphism
Protease inhibitor
Reference proteome
Repeat
Serine protease inhibitor
Signal
Sulfation
Thrombophilia