Names & Taxonomy
- Uniprot ID:
- P05543
- Entry Name:
- THBG_HUMAN
- Status:
- reviewed
- Protein Names:
- Thyroxine-binding globulin (Serpin A7) (T4-binding globulin)
- Gene Names:
- SERPINA7 TBG
- Gene Names Primary:
- SERPINA7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 415
- Sequence:
- MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEKGTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Major thyroid hormone transport protein in serum.
- Cross Reference Drug Bank:
- DB00451 DB00279 DB01583
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
serine-type endopeptidase inhibitor activity
negative regulation of endopeptidase activity
thyroid hormone transport - Gene Ontology Biological Process:
- negative regulation of endopeptidase activity
thyroid hormone transport - Gene Ontology Molecular Function:
- serine-type endopeptidase inhibitor activity
- Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Polymorphism
Reference proteome
Secreted
Signal