Names & Taxonomy

Uniprot ID:
P05362
Entry Name:
ICAM1_HUMAN
Status:
reviewed
Protein Names:
Intercellular adhesion molecule 1 (ICAM-1) (Major group rhinovirus receptor) (CD antigen CD54)
Gene Names:
ICAM1
Gene Names Primary:
ICAM1
Organism:
Homo sapiens (Human)

Structure

Length:
532
Sequence:
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
Cross Reference Drug Bank:
DB08818 DB00108
Gene Ontology Go:
cell surface
external side of plasma membrane
extracellular exosome
extracellular space
focal adhesion
immunological synapse
integral component of plasma membrane
membrane
membrane raft
plasma membrane
integrin binding
receptor activity
transmembrane signaling receptor activity
virus receptor activity
acute inflammatory response to antigenic stimulus
adhesion of symbiont to host
cell adhesion
cell adhesion mediated by integrin
cell aging
cellular response to alkaloid
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to nutrient levels
cellular response to tumor necrosis factor
cytokine-mediated signaling pathway
establishment of endothelial barrier
establishment of Sertoli cell barrier
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
interferon-gamma-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
membrane to membrane docking
negative regulation of calcium ion transport
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
ovarian follicle development
positive regulation of actin filament polymerization
positive regulation of cellular extravasation
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of vasoconstriction
receptor-mediated virion attachment to host cell
regulation of cell adhesion
regulation of cell shape
regulation of immune response
regulation of leukocyte mediated cytotoxicity
regulation of ruffle assembly
response to amino acid
response to amphetamine
response to copper ion
response to drug
response to ethanol
response to gonadotropin
response to ionizing radiation
response to organic cyclic compound
response to sulfur dioxide
sensory perception of sound
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
T cell antigen processing and presentation
Gene Ontology Biological Process:
acute inflammatory response to antigenic stimulus
adhesion of symbiont to host
cell adhesion
cell adhesion mediated by integrin
cell aging
cellular response to alkaloid
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to interleukin-1
cellular response to lipopolysaccharide
cellular response to nutrient levels
cellular response to tumor necrosis factor
cytokine-mediated signaling pathway
establishment of endothelial barrier
establishment of Sertoli cell barrier
extracellular matrix organization
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
interferon-gamma-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
membrane to membrane docking
negative regulation of calcium ion transport
negative regulation of endothelial cell apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
ovarian follicle development
positive regulation of actin filament polymerization
positive regulation of cellular extravasation
positive regulation of ERK1 and ERK2 cascade
positive regulation of GTPase activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of vasoconstriction
receptor-mediated virion attachment to host cell
regulation of cell adhesion
regulation of cell shape
regulation of immune response
regulation of leukocyte mediated cytotoxicity
regulation of ruffle assembly
response to amino acid
response to amphetamine
response to copper ion
response to drug
response to ethanol
response to gonadotropin
response to ionizing radiation
response to organic cyclic compound
response to sulfur dioxide
sensory perception of sound
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
T cell antigen processing and presentation
Gene Ontology Molecular Function:
integrin binding
receptor activity
transmembrane signaling receptor activity
virus receptor activity
Gene Ontology Cellular Component:
cell surface
external side of plasma membrane
extracellular exosome
extracellular space
focal adhesion
immunological synapse
integral component of plasma membrane
membrane
membrane raft
plasma membrane
Keywords:
3D-structure
Cell adhesion
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunoglobulin domain
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation

Publication

PubMed ID:
3340213 3349522 2544880 1680919 14702039 15489334 1983003 15572059 2538243 1968231 11173916 11160747 11413168 16335952 17174307 17875742 18669648 19159218 19139490 19349973 20068231 21269460 24275569 25944712 9539702 9539703 10562537 12526797 15099525 16004874 7525451 8557254 9259284 10391210