Names & Taxonomy
- Uniprot ID:
- P05164
- Entry Name:
- PERM_HUMAN
- Status:
- reviewed
- Protein Names:
- Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]
- Gene Names:
- MPO
- Gene Names Primary:
- MPO
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 745
- Sequence:
- MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
- Catalytic Activity:
- Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.; Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per monomer.;; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; ; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.;
- Active Site:
- ACT_SITE 261 261 Proton acceptor.
- Cross Reference Drug Bank:
- DB00233 DB00006 DB02300 DB06774 DB00958 DB00833 DB00535 DB00515 DB00847 DB00250 DB01225 DB00062 DB00583 DB01065 DB00244 DB00461 DB00104 DB00526 DB00550 DB00208 DB06823 DB00500
- Gene Ontology Go:
- azurophil granule
extracellular exosome
extracellular space
lysosome
mitochondrion
nucleus
secretory granule
chromatin binding
heme binding
heparin binding
metal ion binding
peroxidase activity
aging
defense response
defense response to fungus
hydrogen peroxide catabolic process
hypochlorous acid biosynthetic process
low-density lipoprotein particle remodeling
negative regulation of apoptotic process
negative regulation of growth of symbiont in host
oxidation-reduction process
removal of superoxide radicals
respiratory burst involved in defense response
response to food
response to gold nanoparticle
response to lipopolysaccharide
response to mechanical stimulus
response to oxidative stress
response to yeast - Gene Ontology Biological Process:
- aging
defense response
defense response to fungus
hydrogen peroxide catabolic process
hypochlorous acid biosynthetic process
low-density lipoprotein particle remodeling
negative regulation of apoptotic process
negative regulation of growth of symbiont in host
oxidation-reduction process
removal of superoxide radicals
respiratory burst involved in defense response
response to food
response to gold nanoparticle
response to lipopolysaccharide
response to mechanical stimulus
response to oxidative stress
response to yeast - Gene Ontology Molecular Function:
- chromatin binding
heme binding
heparin binding
metal ion binding
peroxidase activity - Gene Ontology Cellular Component:
- azurophil granule
extracellular exosome
extracellular space
lysosome
mitochondrion
nucleus
secretory granule - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Heme
Hydrogen peroxide
Iron
Lysosome
Metal-binding
Nitration
Oxidation
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Signal