Names & Taxonomy

Uniprot ID:
P05154
Entry Name:
IPSP_HUMAN
Status:
reviewed
Protein Names:
Plasma serine protease inhibitor (Acrosomal serine protease inhibitor) (Plasminogen activator inhibitor 3) (PAI-3) (PAI3) (Protein C inhibitor) (PCI) (Serpin A5)
Gene Names:
SERPINA5 PCI PLANH3 PROCI
Gene Names Primary:
SERPINA5
Organism:
Homo sapiens (Human)

Structure

Length:
406
Sequence:
MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted, extracellular space

Function

Function:
Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
Enzyme Regulation:
ENZYME REGULATION: Its inhibitory activity is greatly enhanced in the presence of glycosaminoglycans, heparin, thrombomodulin and phospholipids vesicles.
Cross Reference Drug Bank:
DB00055 DB00013
Gene Ontology Go:
acrosomal membrane
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
membrane
platelet alpha granule
platelet dense tubular network
protein C inhibitor-coagulation factor V complex
protein C inhibitor-coagulation factor Xa complex
protein C inhibitor-coagulation factor XI complex
protein C inhibitor-KLK3 complex
protein C inhibitor-plasma kallikrein complex
protein C inhibitor-PLAT complex
protein C inhibitor-PLAU complex
protein C inhibitor-thrombin complex
protein C inhibitor-TMPRSS11E complex
protein C inhibitor-TMPRSS7 complex
protein complex
acrosin binding
glycosaminoglycan binding
heparin binding
phosphatidylcholine binding
protease binding
retinoic acid binding
serine-type endopeptidase inhibitor activity
blood coagulation
fusion of sperm to egg plasma membrane
lipid transport
negative regulation of endopeptidase activity
negative regulation of hydrolase activity
spermatogenesis
Gene Ontology Biological Process:
blood coagulation
fusion of sperm to egg plasma membrane
lipid transport
negative regulation of endopeptidase activity
negative regulation of hydrolase activity
spermatogenesis
Gene Ontology Molecular Function:
acrosin binding
glycosaminoglycan binding
heparin binding
phosphatidylcholine binding
protease binding
retinoic acid binding
serine-type endopeptidase inhibitor activity
Gene Ontology Cellular Component:
acrosomal membrane
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
membrane
platelet alpha granule
platelet dense tubular network
protein C inhibitor-coagulation factor V complex
protein C inhibitor-coagulation factor Xa complex
protein C inhibitor-coagulation factor XI complex
protein C inhibitor-KLK3 complex
protein C inhibitor-plasma kallikrein complex
protein C inhibitor-PLAT complex
protein C inhibitor-PLAU complex
protein C inhibitor-thrombin complex
protein C inhibitor-TMPRSS11E complex
protein C inhibitor-TMPRSS7 complex
protein complex
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Fertilization
Glycoprotein
Heparin-binding
Lipid transport
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Serine protease inhibitor
Signal
Transport

Publication

PubMed ID:
3027058 2173165 1714450 8148499 8713781 12508121 15489334 8471250 17974005 2556811 6323392 3501295 2844223 1725227 1372913 7521127 7548057 8536714 8665956 9473218 9510955 9556620 10340997 11722589 14696115 15328353 15140131 14760718 15853774 16335952 17706750 18467335 18362344 21056543 22171320 2172989 12575940 17337440 18974053 10391209