Names & Taxonomy
- Uniprot ID:
- P05113
- Entry Name:
- IL5_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-5 (IL-5) (B-cell differentiation factor I) (Eosinophil differentiation factor) (T-cell replacing factor) (TRF)
- Gene Names:
- IL5
- Gene Names Primary:
- IL5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 134
- Sequence:
- MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
- Cross Reference Drug Bank:
- DB06612 DB01411
- Gene Ontology Go:
- extracellular region
extracellular space
intracellular
cytokine activity
interleukin-5 receptor binding
activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
inflammatory response
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
positive regulation of B cell proliferation
positive regulation of eosinophil differentiation
positive regulation of immunoglobulin secretion
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of podosome assembly
positive regulation of sequence-specific DNA binding transcription factor activity
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPKK activity
axon guidance
cytokine-mediated signaling pathway
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
inflammatory response
innate immune response
insulin receptor signaling pathway
MAPK cascade
neurotrophin TRK receptor signaling pathway
positive regulation of B cell proliferation
positive regulation of eosinophil differentiation
positive regulation of immunoglobulin secretion
positive regulation of JAK-STAT cascade
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of podosome assembly
positive regulation of sequence-specific DNA binding transcription factor activity
Ras protein signal transduction
small GTPase mediated signal transduction
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- cytokine activity
interleukin-5 receptor binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
intracellular - Keywords:
- 3D-structure
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal - Interacts With:
- P32927; Q01344