Names & Taxonomy
- Uniprot ID:
- P05107
- Entry Name:
- ITB2_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
- Gene Names:
- ITGB2 CD18 MFI7
- Gene Names Primary:
- ITGB2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 769
- Sequence:
- MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
- Cross Reference Drug Bank:
- DB00641
- Gene Ontology Go:
- cell surface
extracellular exosome
extracellular vesicle
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane
receptor complex
secretory granule
cell adhesion molecule binding
glycoprotein binding
ICAM-3 receptor activity
metal ion binding
protein kinase binding
aging
apoptotic process
blood coagulation
cell adhesion
cell-cell signaling
cell-matrix adhesion
cellular extravasation
cellular response to low-density lipoprotein particle stimulus
endodermal cell differentiation
endothelial cell migration
extracellular matrix organization
heterotypic cell-cell adhesion
inflammatory response
innate immune response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
leukocyte migration involved in inflammatory response
natural killer cell activation
neutrophil chemotaxis
positive regulation of angiogenesis
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
receptor clustering
receptor internalization
regulation of cell shape
regulation of immune response
regulation of peptidyl-tyrosine phosphorylation
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- aging
apoptotic process
blood coagulation
cell adhesion
cell-cell signaling
cell-matrix adhesion
cellular extravasation
cellular response to low-density lipoprotein particle stimulus
endodermal cell differentiation
endothelial cell migration
extracellular matrix organization
heterotypic cell-cell adhesion
inflammatory response
innate immune response
integrin-mediated signaling pathway
leukocyte cell-cell adhesion
leukocyte migration
leukocyte migration involved in inflammatory response
natural killer cell activation
neutrophil chemotaxis
positive regulation of angiogenesis
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric oxide biosynthetic process
receptor clustering
receptor internalization
regulation of cell shape
regulation of immune response
regulation of peptidyl-tyrosine phosphorylation
toll-like receptor 4 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- cell adhesion molecule binding
glycoprotein binding
ICAM-3 receptor activity
metal ion binding
protein kinase binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
extracellular vesicle
integrin alphaL-beta2 complex
integrin complex
membrane
plasma membrane
receptor complex
secretory granule - Keywords:
- 3D-structure
Cell adhesion
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Integrin
Membrane
Metal-binding
Phosphoprotein
Pyrrolidone carboxylic acid
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P00519; Q7Z3S9; P35241; Q9Y4G6