Names & Taxonomy
- Uniprot ID:
- P05106
- Entry Name:
- ITB3_HUMAN
- Status:
- reviewed
- Protein Names:
- Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
- Gene Names:
- ITGB3 GP3A
- Gene Names Primary:
- ITGB3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 788
- Sequence:
- MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity).
- Cross Reference Drug Bank:
- DB00054 DB00098 DB00063 DB00775
- Gene Ontology Go:
- alphav-beta3 integrin-vitronectin complex
cell surface
extracellular exosome
filopodium membrane
focal adhesion
integral component of plasma membrane
integrin alphav-beta3 complex
integrin complex
lamellipodium membrane
melanosome
microvillus membrane
nucleus
plasma membrane
platelet alpha granule membrane
receptor complex
ruffle membrane
cell adhesion molecule binding
enzyme binding
extracellular matrix binding
fibronectin binding
identical protein binding
platelet-derived growth factor receptor binding
protease binding
protein disulfide isomerase activity
vascular endothelial growth factor receptor 2 binding
virus receptor activity
activation of protein kinase activity
angiogenesis involved in wound healing
apolipoprotein A-I-mediated signaling pathway
axon guidance
blood coagulation
cell adhesion
cell growth
cell migration
cell-matrix adhesion
cell-substrate adhesion
cell-substrate junction assembly
extracellular matrix organization
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte migration
mesodermal cell differentiation
negative chemotaxis
negative regulation of lipid storage
negative regulation of lipid transport
negative regulation of lipoprotein metabolic process
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of macrophage derived foam cell differentiation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein phosphorylation
positive regulation of vascular endothelial growth factor receptor signaling pathway
protein folding
regulation of bone resorption
smooth muscle cell migration
substrate adhesion-dependent cell spreading
tube development
vascular endothelial growth factor receptor signaling pathway
viral entry into host cell
wound healing - Gene Ontology Biological Process:
- activation of protein kinase activity
angiogenesis involved in wound healing
apolipoprotein A-I-mediated signaling pathway
axon guidance
blood coagulation
cell adhesion
cell growth
cell-matrix adhesion
cell migration
cell-substrate adhesion
cell-substrate junction assembly
extracellular matrix organization
heterotypic cell-cell adhesion
integrin-mediated signaling pathway
leukocyte migration
mesodermal cell differentiation
negative chemotaxis
negative regulation of lipid storage
negative regulation of lipid transport
negative regulation of lipoprotein metabolic process
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of macrophage derived foam cell differentiation
platelet activation
platelet aggregation
platelet degranulation
positive regulation of endothelial cell migration
positive regulation of endothelial cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein phosphorylation
positive regulation of vascular endothelial growth factor receptor signaling pathway
protein folding
regulation of bone resorption
smooth muscle cell migration
substrate adhesion-dependent cell spreading
tube development
vascular endothelial growth factor receptor signaling pathway
viral entry into host cell
wound healing - Gene Ontology Molecular Function:
- cell adhesion molecule binding
enzyme binding
extracellular matrix binding
fibronectin binding
identical protein binding
platelet-derived growth factor receptor binding
protease binding
protein disulfide isomerase activity
vascular endothelial growth factor receptor 2 binding
virus receptor activity - Gene Ontology Cellular Component:
- alphav-beta3 integrin-vitronectin complex
cell surface
extracellular exosome
filopodium membrane
focal adhesion
integral component of plasma membrane
integrin alphav-beta3 complex
integrin complex
lamellipodium membrane
melanosome
microvillus membrane
nucleus
plasma membrane
platelet alpha granule membrane
receptor complex
ruffle membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell junction
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Integrin
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Itself; P06935; P05094; P08514; P06756; F5HB81; Q62101; P18031; P05480; P54939; Q9Y490; P26039
Publication
- PubMed ID:
- 3494014 2452834 2345548 9195946 15489334 8298129 3165296 1953640 12665801 2341395 2145280 1382574 3801670 2787511 2001252 7519807 8631894 9618541 10397733 10896934 11160695 11940607 11807098 12695522 15156152 15834425 15466936 16216233 16051604 16322781 16335952 16982628 16263699 17635696 18088087 18045938 19494351 19159218 20702409 23658209 24478423 11546839 17583734 7878622 2565345 1430225 8093349 7694683 8132570 2392682 1371279 1602006 1438206 8781422 9376589 9215749 9790984 9684783 10233432 10391209 11588040 12036875 11897046 12083483 12353082 15583747 15634267 15748237 18065693 20020534