Names & Taxonomy
- Uniprot ID:
- P05093
- Entry Name:
- CP17A_HUMAN
- Status:
- reviewed
- Protein Names:
- Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 4.1.2.30) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
- Gene Names:
- CYP17A1 CYP17 S17AH
- Gene Names Primary:
- CYP17A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 508
- Sequence:
- MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
- Pathway:
- Lipid metabolism; steroid biosynthesis.
- Catalytic Activity:
- A C(21)-steroid + + O(2) = a 17-alpha-hydroxy-C(21)-steroid + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Enzyme Regulation:
- ENZYME REGULATION: Regulated predominantly by intracellular cAMP levels.
- Cross Reference Drug Bank:
- DB05812 DB01424 DB01234 DB01233 DB00396
- Gene Ontology Go:
- axon
endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion
neuronal cell body
17-alpha-hydroxyprogesterone aldolase activity
heme binding
iron ion binding
oxygen binding
steroid 17-alpha-monooxygenase activity
adrenal gland development
androgen biosynthetic process
biphenyl metabolic process
cellular response to antibiotic
cellular response to gonadotropin stimulus
cellular response to lipopolysaccharide
dibenzo-p-dioxin metabolic process
glucocorticoid biosynthetic process
hippocampus development
hormone biosynthetic process
Leydig cell differentiation
ovulation
phenol-containing compound metabolic process
phthalate metabolic process
positive regulation of steroid hormone biosynthetic process
progesterone metabolic process
response to acetate
response to cAMP
response to cytokine
response to drug
response to fungicide
response to herbicide
response to insecticide
response to ionizing radiation
response to methylmercury
response to nutrient levels
response to retinoic acid
response to steroid hormone
sex differentiation
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- adrenal gland development
androgen biosynthetic process
biphenyl metabolic process
cellular response to antibiotic
cellular response to gonadotropin stimulus
cellular response to lipopolysaccharide
dibenzo-p-dioxin metabolic process
glucocorticoid biosynthetic process
hippocampus development
hormone biosynthetic process
Leydig cell differentiation
ovulation
phenol-containing compound metabolic process
phthalate metabolic process
positive regulation of steroid hormone biosynthetic process
progesterone metabolic process
response to acetate
response to cAMP
response to cytokine
response to drug
response to fungicide
response to herbicide
response to insecticide
response to ionizing radiation
response to methylmercury
response to nutrient levels
response to retinoic acid
response to steroid hormone
sex differentiation
small molecule metabolic process
steroid biosynthetic process
steroid metabolic process
sterol metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- 17-alpha-hydroxyprogesterone aldolase activity
heme binding
iron ion binding
oxygen binding
steroid 17-alpha-monooxygenase activity - Gene Ontology Cellular Component:
- axon
endoplasmic reticulum
endoplasmic reticulum membrane
mitochondrion
neuronal cell body - Keywords:
- 3D-structure
Complete proteome
Congenital adrenal hyperplasia
Disease mutation
Heme
Iron
Lyase
Membrane
Metal-binding
Monooxygenase
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Steroidogenesis