Names & Taxonomy
- Uniprot ID:
- P04632
- Entry Name:
- CPNS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)
- Gene Names:
- CAPNS1 CAPN4 CAPNS
- Gene Names Primary:
- CAPNS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 268
- Sequence:
- MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNIEANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
- Gene Ontology Go:
- cytosol
extracellular exosome
membrane
plasma membrane
calcium ion binding
calcium-dependent cysteine-type endopeptidase activity
extracellular matrix disassembly
extracellular matrix organization
positive regulation of cell proliferation
regulation of macroautophagy - Gene Ontology Biological Process:
- extracellular matrix disassembly
extracellular matrix organization
positive regulation of cell proliferation
regulation of macroautophagy - Gene Ontology Molecular Function:
- calcium-dependent cysteine-type endopeptidase activity
calcium ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
membrane
plasma membrane - Keywords:
- 3D-structure
Acetylation
Calcium
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat - Interacts With:
- Q6RW13; P17655; P20936