Names & Taxonomy

Uniprot ID:
P04234
Entry Name:
CD3D_HUMAN
Status:
reviewed
Protein Names:
T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
Gene Names:
CD3D T3D
Gene Names Primary:
CD3D
Organism:
Homo sapiens (Human)

Structure

Length:
171
Sequence:
MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Function

Function:
The CD3 complex mediates signal transduction.
Cross Reference Drug Bank:
DB09052 DB00075
Gene Ontology Go:
alpha-beta T cell receptor complex
cytoplasm
integral component of membrane
plasma membrane
T cell receptor complex
protein heterodimerization activity
transcription coactivator activity
transmembrane signaling receptor activity
cell surface receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive thymic T cell selection
regulation of immune response
T cell costimulation
T cell differentiation
T cell receptor signaling pathway
Gene Ontology Biological Process:
cell surface receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive thymic T cell selection
regulation of immune response
T cell costimulation
T cell differentiation
T cell receptor signaling pathway
Gene Ontology Molecular Function:
protein heterodimerization activity
transcription coactivator activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
alpha-beta T cell receptor complex
cytoplasm
integral component of membrane
plasma membrane
T cell receptor complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
SCID
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
2939461 6095101 3488209 15028279 16554811 15489334 2540970 14602880 12522270 15144186 15546002 19690332 21883749 15534202