Names & Taxonomy
- Uniprot ID:
- P04234
- Entry Name:
- CD3D_HUMAN
- Status:
- reviewed
- Protein Names:
- T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
- Gene Names:
- CD3D T3D
- Gene Names Primary:
- CD3D
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 171
- Sequence:
- MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDLGKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLALGVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- The CD3 complex mediates signal transduction.
- Cross Reference Drug Bank:
- DB09052 DB00075
- Gene Ontology Go:
- alpha-beta T cell receptor complex
cytoplasm
integral component of membrane
plasma membrane
T cell receptor complex
protein heterodimerization activity
transcription coactivator activity
transmembrane signaling receptor activity
cell surface receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive thymic T cell selection
regulation of immune response
T cell costimulation
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive thymic T cell selection
regulation of immune response
T cell costimulation
T cell differentiation
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- protein heterodimerization activity
transcription coactivator activity
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- alpha-beta T cell receptor complex
cytoplasm
integral component of membrane
plasma membrane
T cell receptor complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
SCID
Signal
Transmembrane
Transmembrane helix