Names & Taxonomy
- Uniprot ID:
- P04183
- Entry Name:
- KITH_HUMAN
- Status:
- reviewed
- Protein Names:
- Thymidine kinase, cytosolic (EC 2.7.1.21)
- Gene Names:
- TK1
- Gene Names Primary:
- TK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 234
- Sequence:
- MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Catalytic Activity:
- ATP + thymidine = ADP + thymidine 5'-phosphate.
- Active Site:
- ACT_SITE 98 98 Proton acceptor.
- Cross Reference Drug Bank:
- DB00432 DB00495
- Gene Ontology Go:
- cytosol
ATP binding
identical protein binding
nucleoside kinase activity
thymidine kinase activity
zinc ion binding
digestive tract development
DNA biosynthetic process
fetal process involved in parturition
liver development
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
protein homotetramerization
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
response to copper ion
response to cortisol
response to nutrient levels
response to toxic substance
skeletal muscle cell proliferation
small molecule metabolic process
thymidine metabolic process - Gene Ontology Biological Process:
- digestive tract development
DNA biosynthetic process
fetal process involved in parturition
liver development
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
nucleotide biosynthetic process
protein homotetramerization
pyrimidine nucleobase metabolic process
pyrimidine nucleoside salvage
response to copper ion
response to cortisol
response to nutrient levels
response to toxic substance
skeletal muscle cell proliferation
small molecule metabolic process
thymidine metabolic process - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
nucleoside kinase activity
thymidine kinase activity
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
ATP-binding
Acetylation
Complete proteome
Cytoplasm
DNA synthesis
Kinase
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transferase
Zinc - Interacts With:
- Itself; Q1RN33