Names & Taxonomy
- Uniprot ID:
- P04053
- Entry Name:
- TDT_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase)
- Gene Names:
- DNTT TDT
- Gene Names Primary:
- DNTT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 509
- Sequence:
- MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
- Catalytic Activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Gene Ontology Go:
- cytoplasm
nucleoplasm
nucleus
DNA binding
DNA nucleotidylexotransferase activity
DNA-directed DNA polymerase activity
metal ion binding
DNA metabolic process
DNA modification - Gene Ontology Biological Process:
- DNA metabolic process
DNA modification - Gene Ontology Molecular Function:
- DNA binding
DNA-directed DNA polymerase activity
DNA nucleotidylexotransferase activity
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm
nucleus - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Magnesium
Metal-binding
Nucleotidyltransferase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Terminal addition
Transferase - Interacts With:
- Q04864