Names & Taxonomy

Uniprot ID:
P04000
Entry Name:
OPSR_HUMAN
Status:
reviewed
Protein Names:
Long-wave-sensitive opsin 1 (Red cone photoreceptor pigment) (Red-sensitive opsin) (ROP)
Gene Names:
OPN1LW RCP
Gene Names Primary:
OPN1LW
Organism:
Homo sapiens (Human)

Structure

Length:
364
Sequence:
MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Gene Ontology Go:
integral component of plasma membrane
photoreceptor outer segment membrane
G-protein coupled receptor activity
photoreceptor activity
phototransduction, visible light
positive regulation of cytokinesis
protein-chromophore linkage
retinoid metabolic process
signal transduction
visual perception
Gene Ontology Biological Process:
phototransduction, visible light
positive regulation of cytokinesis
protein-chromophore linkage
retinoid metabolic process
signal transduction
visual perception
Gene Ontology Molecular Function:
G-protein coupled receptor activity
photoreceptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
photoreceptor outer segment membrane
Keywords:
3D-structure
Chromophore
Complete proteome
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Photoreceptor protein
Polymorphism
Receptor
Reference proteome
Retinal protein
Sensory transduction
Transducer
Transmembrane
Transmembrane helix
Vision

Publication

PubMed ID:
2937147 15772651 3303660 1557123 8213841 8666378 12051694