Names & Taxonomy
- Uniprot ID:
- P03989
- Entry Name:
- 1B27_HUMAN
- Status:
- reviewed
- Protein Names:
- HLA class I histocompatibility antigen, B-27 alpha chain (MHC class I antigen B*27)
- Gene Names:
- HLA-B HLAB
- Gene Names Primary:
- HLA-B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 362
- Sequence:
- MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRFDSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQNMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSLTA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- Involved in the presentation of foreign antigens to the immune system.
- Gene Ontology Go:
- cell surface
early endosome membrane
endoplasmic reticulum
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of lumenal side of endoplasmic reticulum membrane
membrane
MHC class I protein complex
phagocytic vesicle membrane
plasma membrane
peptide antigen binding
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
defense response
detection of bacterium
immune response
interferon-gamma-mediated signaling pathway
regulation of immune response
type I interferon signaling pathway
viral process - Gene Ontology Biological Process:
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of peptide antigen via MHC class I
cytokine-mediated signaling pathway
defense response
detection of bacterium
immune response
interferon-gamma-mediated signaling pathway
regulation of immune response
type I interferon signaling pathway
viral process - Gene Ontology Molecular Function:
- peptide antigen binding
- Gene Ontology Cellular Component:
- cell surface
early endosome membrane
endoplasmic reticulum
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi apparatus
Golgi membrane
integral component of lumenal side of endoplasmic reticulum membrane
membrane
MHC class I protein complex
phagocytic vesicle membrane
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Immunity
MHC I
Membrane
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Ubl conjugation