Names & Taxonomy
- Uniprot ID:
- P03923
- Entry Name:
- NU6M_HUMAN
- Status:
- reviewed
- Protein Names:
- NADH-ubiquinone oxidoreductase chain 6 (EC 1.6.5.3) (NADH dehydrogenase subunit 6)
- Gene Names:
- MT-ND6 MTND6 NADH6 ND6
- Gene Names Primary:
- MT-ND6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 174
- Sequence:
- MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
respiratory chain
NADH dehydrogenase (ubiquinone) activity
cellular metabolic process
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to cocaine
response to hydrogen peroxide
response to nicotine
small molecule metabolic process - Gene Ontology Biological Process:
- cellular metabolic process
mitochondrial respiratory chain complex I assembly
respiratory electron transport chain
response to cocaine
response to hydrogen peroxide
response to nicotine
small molecule metabolic process - Gene Ontology Molecular Function:
- NADH dehydrogenase (ubiquinone) activity
- Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
respiratory chain - Keywords:
- Complete proteome
Disease mutation
Dystonia
Electron transport
Leber hereditary optic neuropathy
MELAS syndrome
Membrane
Mitochondrion
NAD
Oxidoreductase
Polymorphism
Reference proteome
Respiratory chain
Transmembrane
Transmembrane helix
Transport
Ubiquinone