Names & Taxonomy

Uniprot ID:
P02787
Entry Name:
TRFE_HUMAN
Status:
reviewed
Protein Names:
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)
Gene Names:
TF PRO1400
Gene Names Orf:
PRO1400
Gene Names Primary:
TF
Organism:
Homo sapiens (Human)

Structure

Length:
698
Sequence:
MRLAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Cross Reference Drug Bank:
DB01370 DB01294 DB05260 DB00893
Gene Ontology Go:
apical plasma membrane
basal part of cell
basal plasma membrane
blood microparticle
cell surface
coated pit
cytoplasmic, membrane-bounded vesicle
early endosome
endocytic vesicle
endosome membrane
extracellular exosome
extracellular region
extracellular space
extrinsic component of external side of plasma membrane
HFE-transferrin receptor complex
late endosome
perinuclear region of cytoplasm
recycling endosome
secretory granule lumen
vesicle
ferric iron binding
ferric iron transmembrane transporter activity
ferrous iron binding
transferrin receptor binding
blood coagulation
cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
platelet activation
platelet degranulation
positive regulation of receptor-mediated endocytosis
regulation of protein stability
retina homeostasis
transferrin transport
transmembrane transport
Gene Ontology Biological Process:
blood coagulation
cellular iron ion homeostasis
cellular response to iron ion
ferrous iron import into cell
iron ion homeostasis
platelet activation
platelet degranulation
positive regulation of receptor-mediated endocytosis
regulation of protein stability
retina homeostasis
transferrin transport
transmembrane transport
Gene Ontology Molecular Function:
ferric iron binding
ferric iron transmembrane transporter activity
ferrous iron binding
transferrin receptor binding
Gene Ontology Cellular Component:
apical plasma membrane
basal part of cell
basal plasma membrane
blood microparticle
cell surface
coated pit
cytoplasmic, membrane-bounded vesicle
early endosome
endocytic vesicle
endosome membrane
extracellular exosome
extracellular region
extracellular space
extrinsic component of external side of plasma membrane
HFE-transferrin receptor complex
late endosome
perinuclear region of cytoplasm
recycling endosome
secretory granule lumen
vesicle
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Ion transport
Iron
Iron transport
Metal-binding
Methylation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transport
Interacts With:
P01350

Publication

PubMed ID:
6585826 3678832 1809186 11110675 16641997 15489334 3106157 3786138 6833213 10931525 3858812 7498159 6322780 9272172 2780570 6953407 1932003 15084671 14760718 15536627 16335952 16740002 19159218 19139490 19838169 22905912 24275569 26091039 9609685 9760232 10029548 9358047 9803271 11703331 11702220 15466165 21269460