Names & Taxonomy
- Uniprot ID:
- P02774
- Entry Name:
- VTDB_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)
- Gene Names:
- GC
- Gene Names Primary:
- GC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 474
- Sequence:
- MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
- Cross Reference Drug Bank:
- DB01436 DB00169 DB04224
- Gene Ontology Go:
- axon
blood microparticle
cytosol
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
perinuclear region of cytoplasm
actin binding
calcidiol binding
vitamin D binding
vitamin transporter activity
fat-soluble vitamin metabolic process
female pregnancy
lactation
response to estradiol
response to nutrient levels
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
vitamin transport - Gene Ontology Biological Process:
- fat-soluble vitamin metabolic process
female pregnancy
lactation
response to estradiol
response to nutrient levels
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
vitamin transport - Gene Ontology Molecular Function:
- actin binding
calcidiol binding
vitamin D binding
vitamin transporter activity - Gene Ontology Cellular Component:
- axon
blood microparticle
cytosol
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
perinuclear region of cytoplasm - Keywords:
- 3D-structure
Actin-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transport
Vitamin D