Names & Taxonomy

Uniprot ID:
P02774
Entry Name:
VTDB_HUMAN
Status:
reviewed
Protein Names:
Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)
Gene Names:
GC
Gene Names Primary:
GC
Organism:
Homo sapiens (Human)

Structure

Length:
474
Sequence:
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPKELAKLVNKRSDFASNCCSINSPPLYCDSEIDAELKNIL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Cross Reference Drug Bank:
DB01436 DB00169 DB04224
Gene Ontology Go:
axon
blood microparticle
cytosol
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
perinuclear region of cytoplasm
actin binding
calcidiol binding
vitamin D binding
vitamin transporter activity
fat-soluble vitamin metabolic process
female pregnancy
lactation
response to estradiol
response to nutrient levels
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
vitamin transport
Gene Ontology Biological Process:
fat-soluble vitamin metabolic process
female pregnancy
lactation
response to estradiol
response to nutrient levels
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
vitamin transport
Gene Ontology Molecular Function:
actin binding
calcidiol binding
vitamin D binding
vitamin transporter activity
Gene Ontology Cellular Component:
axon
blood microparticle
cytosol
extracellular exosome
extracellular region
extracellular space
lysosomal lumen
perinuclear region of cytoplasm
Keywords:
3D-structure
Actin-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Transport
Vitamin D

Publication

PubMed ID:
2416779 2415977 7505619 8325650 14702039 15815621 15489334 2958390 2423133 218624 20079467 7725672 16302727 17360250 21269460 1352271 11799400 24275569