Names & Taxonomy

Uniprot ID:
P02766
Entry Name:
TTHY_HUMAN
Status:
reviewed
Protein Names:
Transthyretin (ATTR) (Prealbumin) (TBPA)
Gene Names:
TTR PALB
Gene Names Primary:
TTR
Organism:
Homo sapiens (Human)

Structure

Length:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted. Cytoplasm.

Function

Function:
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Cross Reference Drug Bank:
DB00586 DB00255 DB00861 DB01093 DB00451 DB00279 DB01583
Gene Ontology Go:
cytoplasm
extracellular exosome
extracellular region
extracellular space
protein complex
hormone binding
identical protein binding
cellular protein metabolic process
extracellular matrix organization
fat-soluble vitamin metabolic process
phototransduction, visible light
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
transport
vitamin metabolic process
Gene Ontology Biological Process:
cellular protein metabolic process
extracellular matrix organization
fat-soluble vitamin metabolic process
phototransduction, visible light
retinoid metabolic process
retinol metabolic process
small molecule metabolic process
transport
vitamin metabolic process
Gene Ontology Molecular Function:
hormone binding
identical protein binding
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extracellular region
extracellular space
protein complex
Keywords:
3D-structure
Amyloid
Amyloidosis
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Gamma-carboxyglutamic acid
Glycoprotein
Hormone
Neuropathy
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Thyroid hormone
Transport
Interacts With:
Itself; Q15109; Q01850; P25713; H3BTW2

Publication

PubMed ID:
6093805 2990465 4054629 2995367 3818577 3022108 2015890 1666289 10328977 14702039 15489334 4607556 6300852 6651852 6583672 3135807 1517749 12665801 1932142 7923855 4044580 1979335 7474944 201845 3714052 14760718 16335952 18221012 19167329 24275569 4216640 671542 8382610 8428915 7754382 9818054 9733771 9789022 10052934 10986125 10742177 11560492 11243784 12403615 12820260 14583036 14711308 15735344 15981995 16185074 15826192 15769474 16627944 17175208 17196219 18155178 19021760 18095641 18811132 18662699 7599630 6487335 3722385 3675594 2891727 2161654 2363717 1877623 1656975 1997217 2046936 1570831 1734866 1520326 1520336 1544214 1351039 1301926 1362222 1436517 8352764 8038017 8257997 8095302 8019560 8081397 8089102 7914929 8133316 7910950 8309582 7655883 7850982 8579098 9066351 8990019 9605286 10036587 10627135 10694917 10671063 9818883 10211412 10439117 10611950 10529370 10071047 10436378 10842705 10842718 10882995 11445644 12557757 11866053 12050338 12771253 12876326 15214015 15478468 15217993 17453626 17577687 17503405 17635579 23317988