Names & Taxonomy

Uniprot ID:
P02753
Entry Name:
RET4_HUMAN
Status:
reviewed
Protein Names:
Retinol-binding protein 4 (Plasma retinol-binding protein) (PRBP) (RBP) [Cleaved into: Plasma retinol-binding protein(1-182); Plasma retinol-binding protein(1-181); Plasma retinol-binding protein(1-179); Plasma retinol-binding protein(1-176)]
Gene Names:
RBP4 PRO2222
Gene Names Orf:
PRO2222
Gene Names Primary:
RBP4
Organism:
Homo sapiens (Human)

Structure

Length:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Cross Reference Drug Bank:
DB00162
Gene Ontology Go:
cytosol
extracellular exosome
extracellular region
extracellular space
protein complex
retinal binding
retinol binding
retinol transporter activity
cardiac muscle tissue development
embryonic organ morphogenesis
embryonic retina morphogenesis in camera-type eye
embryonic skeletal system development
eye development
fat-soluble vitamin metabolic process
female genitalia morphogenesis
gluconeogenesis
glucose homeostasis
heart development
heart trabecula formation
lung development
maintenance of gastrointestinal epithelium
negative regulation of cardiac muscle cell proliferation
phototransduction, visible light
positive regulation of immunoglobulin secretion
positive regulation of insulin secretion
response to ethanol
response to retinoic acid
retinoid metabolic process
retinol metabolic process
retinol transport
small molecule metabolic process
urinary bladder development
uterus development
vagina development
visual perception
vitamin metabolic process
Gene Ontology Biological Process:
cardiac muscle tissue development
embryonic organ morphogenesis
embryonic retina morphogenesis in camera-type eye
embryonic skeletal system development
eye development
fat-soluble vitamin metabolic process
female genitalia morphogenesis
gluconeogenesis
glucose homeostasis
heart development
heart trabecula formation
lung development
maintenance of gastrointestinal epithelium
negative regulation of cardiac muscle cell proliferation
phototransduction, visible light
positive regulation of immunoglobulin secretion
positive regulation of insulin secretion
response to ethanol
response to retinoic acid
retinoid metabolic process
retinol metabolic process
retinol transport
small molecule metabolic process
urinary bladder development
uterus development
vagina development
visual perception
vitamin metabolic process
Gene Ontology Molecular Function:
retinal binding
retinol binding
retinol transporter activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
extracellular region
extracellular space
protein complex
Keywords:
3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Microphthalmia
Reference proteome
Retinol-binding
Secreted
Sensory transduction
Signal
Transport
Vision
Vitamin A
Interacts With:
O55245

Publication

PubMed ID:
6316270 15164054 15489334 2998779 2444024 6942701 573217 7666002 12237133 12716133 21269460 23189188 24275569 25910211 6540172 2217163 1623143 10052934 9888420 10232633