Names & Taxonomy
- Uniprot ID:
- P02747
- Entry Name:
- C1QC_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement C1q subcomponent subunit C
- Gene Names:
- C1QC C1QG
- Gene Names Primary:
- C1QC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 245
- Sequence:
- MDVGPSSLPHLGLKLLLLLLLLPLRGQANTGCYGIPGMPGLPGAPGKDGYDGLPGPKGEPGIPAIPGIRGPKGQKGEPGLPGHPGKNGPMGPPGMPGVPGPMGIPGEPGEEGRYKQKFQSVFTVTRQTHQPPAPNSLIRFNAVLTNPQGDYDTSTGKFTCKVPGLYYFVYHASHTANLCVLLYRSGVKVVTFCGHTSKTNQVNSGGVLLRLQVGEEVWLAVNDYYDMVGIQGSDSVFSGFLLFPD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
- Cross Reference Drug Bank:
- DB00054 DB00051 DB00092 DB00087 DB00074 DB00112 DB00002 DB00111 DB00095 DB00005 DB00056 DB00078 DB00075 DB00108 DB00110 DB00073 DB00081 DB00072
- Gene Ontology Go:
- blood microparticle
collagen trimer
extracellular exosome
extracellular region
extracellular space
complement activation
complement activation, classical pathway
immune response
innate immune response
negative regulation of granulocyte differentiation
negative regulation of macrophage differentiation - Gene Ontology Biological Process:
- complement activation
complement activation, classical pathway
immune response
innate immune response
negative regulation of granulocyte differentiation
negative regulation of macrophage differentiation - Gene Ontology Cellular Component:
- blood microparticle
collagen trimer
extracellular exosome
extracellular region
extracellular space - Keywords:
- 3D-structure
Collagen
Complement pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Hydroxylation
Immunity
Innate immunity
Reference proteome
Repeat
Secreted
Signal