Names & Taxonomy

Uniprot ID:
P02741
Entry Name:
CRP_HUMAN
Status:
reviewed
Protein Names:
C-reactive protein [Cleaved into: C-reactive protein(1-205)]
Gene Names:
CRP PTX1
Gene Names Primary:
CRP
Organism:
Homo sapiens (Human)

Structure

Length:
224
Sequence:
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 2 calcium ions per subunit.;
Cross Reference Drug Bank:
DB05278
Gene Ontology Go:
extracellular exosome
extracellular region
extracellular space
calcium ion binding
choline binding
complement component C1q binding
low-density lipoprotein particle binding
low-density lipoprotein particle receptor binding
acute-phase response
defense response to Gram-positive bacterium
inflammatory response
negative regulation of lipid storage
negative regulation of macrophage derived foam cell differentiation
negative regulation of vasodilation
opsonization
positive regulation of gene expression
positive regulation of superoxide anion generation
regulation of interleukin-8 secretion
Gene Ontology Biological Process:
acute-phase response
defense response to Gram-positive bacterium
inflammatory response
negative regulation of lipid storage
negative regulation of macrophage derived foam cell differentiation
negative regulation of vasodilation
opsonization
positive regulation of gene expression
positive regulation of superoxide anion generation
regulation of interleukin-8 secretion
Gene Ontology Molecular Function:
calcium ion binding
choline binding
complement component C1q binding
low-density lipoprotein particle binding
low-density lipoprotein particle receptor binding
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
extracellular space
Keywords:
3D-structure
Acute phase
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Disulfide bond
Metal-binding
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Interacts With:
P31995; Q96IJ6

Publication

PubMed ID:
2997165 3840479 14702039 16710414 15489334 6685157 6857266 762075 403526 21037097 7881902 8599761 10368284