Names & Taxonomy

Uniprot ID:
P02649
Entry Name:
APOE_HUMAN
Status:
reviewed
Protein Names:
Apolipoprotein E (Apo-E)
Gene Names:
APOE
Gene Names Primary:
APOE
Organism:
Homo sapiens (Human)

Structure

Length:
317
Sequence:
MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Cross Reference Drug Bank:
DB00062 DB00064
Gene Ontology Go:
blood microparticle
chylomicron
cytoplasm
dendrite
early endosome
endocytic vesicle lumen
endoplasmic reticulum
extracellular exosome
extracellular matrix
extracellular region
extracellular space
extracellular vesicle
Golgi apparatus
high-density lipoprotein particle
intermediate-density lipoprotein particle
low-density lipoprotein particle
membrane
neuronal cell body
nucleus
plasma membrane
very-low-density lipoprotein particle
antioxidant activity
beta-amyloid binding
cholesterol binding
cholesterol transporter activity
heparin binding
identical protein binding
lipid binding
lipid transporter activity
lipoprotein particle binding
low-density lipoprotein particle receptor binding
metal chelating activity
phosphatidylcholine-sterol O-acyltransferase activator activity
phospholipid binding
protein homodimerization activity
tau protein binding
very-low-density lipoprotein particle receptor binding
AMPA glutamate receptor clustering
artery morphogenesis
cellular calcium ion homeostasis
cellular oxidant detoxification
cGMP-mediated signaling
cholesterol biosynthetic process
cholesterol catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
chylomicron remnant clearance
cytoskeleton organization
fat-soluble vitamin metabolic process
fatty acid homeostasis
G-protein coupled receptor signaling pathway
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
high-density lipoprotein particle remodeling
intracellular transport
lipoprotein biosynthetic process
lipoprotein catabolic process
lipoprotein metabolic process
long-chain fatty acid transport
low-density lipoprotein particle remodeling
maintenance of location in cell
negative regulation of beta-amyloid formation
negative regulation of blood coagulation
negative regulation of blood vessel endothelial cell migration
negative regulation of canonical Wnt signaling pathway
negative regulation of cholesterol biosynthetic process
negative regulation of cholesterol efflux
negative regulation of dendritic spine development
negative regulation of dendritic spine maintenance
negative regulation of endothelial cell proliferation
negative regulation of inflammatory response
negative regulation of lipid biosynthetic process
negative regulation of lipid transport across blood brain barrier
negative regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of neuron death
negative regulation of phospholipid efflux
negative regulation of platelet activation
negative regulation of postsynaptic membrane organization
negative regulation of presynaptic membrane organization
neuron projection regeneration
nitric oxide mediated signal transduction
NMDA glutamate receptor clustering
phospholipid efflux
phototransduction, visible light
positive regulation by host of viral process
positive regulation of beta-amyloid formation
positive regulation of cGMP biosynthetic process
positive regulation of cholesterol efflux
positive regulation of cholesterol esterification
positive regulation of dendritic spine development
positive regulation of dendritic spine maintenance
positive regulation of lipid biosynthetic process
positive regulation of lipid transport across blood brain barrier
positive regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of neurofibrillary tangle assembly
positive regulation of neuron death
positive regulation of nitric-oxide synthase activity
positive regulation of phospholipid efflux
positive regulation of postsynaptic membrane organization
positive regulation of presynaptic membrane organization
protein import
receptor-mediated endocytosis
regulation of axon extension
regulation of beta-amyloid clearance
regulation of Cdc42 protein signal transduction
regulation of gene expression
regulation of neuron death
regulation of neuronal synaptic plasticity
regulation of tau-protein kinase activity
response to dietary excess
response to reactive oxygen species
retinoid metabolic process
reverse cholesterol transport
small molecule metabolic process
synaptic transmission, cholinergic
triglyceride catabolic process
triglyceride metabolic process
vasodilation
very-low-density lipoprotein particle clearance
very-low-density lipoprotein particle remodeling
virion assembly
vitamin metabolic process
Gene Ontology Biological Process:
AMPA glutamate receptor clustering
artery morphogenesis
cellular calcium ion homeostasis
cellular oxidant detoxification
cGMP-mediated signaling
cholesterol biosynthetic process
cholesterol catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol metabolic process
chylomicron remnant clearance
cytoskeleton organization
fat-soluble vitamin metabolic process
fatty acid homeostasis
G-protein coupled receptor signaling pathway
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
high-density lipoprotein particle remodeling
intracellular transport
lipoprotein biosynthetic process
lipoprotein catabolic process
lipoprotein metabolic process
long-chain fatty acid transport
low-density lipoprotein particle remodeling
maintenance of location in cell
negative regulation of beta-amyloid formation
negative regulation of blood coagulation
negative regulation of blood vessel endothelial cell migration
negative regulation of canonical Wnt signaling pathway
negative regulation of cholesterol biosynthetic process
negative regulation of cholesterol efflux
negative regulation of dendritic spine development
negative regulation of dendritic spine maintenance
negative regulation of endothelial cell proliferation
negative regulation of inflammatory response
negative regulation of lipid biosynthetic process
negative regulation of lipid transport across blood brain barrier
negative regulation of MAP kinase activity
negative regulation of neuron apoptotic process
negative regulation of neuron death
negative regulation of phospholipid efflux
negative regulation of platelet activation
negative regulation of postsynaptic membrane organization
negative regulation of presynaptic membrane organization
neuron projection regeneration
nitric oxide mediated signal transduction
NMDA glutamate receptor clustering
phospholipid efflux
phototransduction, visible light
positive regulation by host of viral process
positive regulation of beta-amyloid formation
positive regulation of cGMP biosynthetic process
positive regulation of cholesterol efflux
positive regulation of cholesterol esterification
positive regulation of dendritic spine development
positive regulation of dendritic spine maintenance
positive regulation of lipid biosynthetic process
positive regulation of lipid transport across blood brain barrier
positive regulation of low-density lipoprotein particle receptor catabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of neurofibrillary tangle assembly
positive regulation of neuron death
positive regulation of nitric-oxide synthase activity
positive regulation of phospholipid efflux
positive regulation of postsynaptic membrane organization
positive regulation of presynaptic membrane organization
protein import
receptor-mediated endocytosis
regulation of axon extension
regulation of beta-amyloid clearance
regulation of Cdc42 protein signal transduction
regulation of gene expression
regulation of neuronal synaptic plasticity
regulation of neuron death
regulation of tau-protein kinase activity
response to dietary excess
response to reactive oxygen species
retinoid metabolic process
reverse cholesterol transport
small molecule metabolic process
synaptic transmission, cholinergic
triglyceride catabolic process
triglyceride metabolic process
vasodilation
very-low-density lipoprotein particle clearance
very-low-density lipoprotein particle remodeling
virion assembly
vitamin metabolic process
Gene Ontology Molecular Function:
antioxidant activity
beta-amyloid binding
cholesterol binding
cholesterol transporter activity
heparin binding
identical protein binding
lipid binding
lipid transporter activity
lipoprotein particle binding
low-density lipoprotein particle receptor binding
metal chelating activity
phosphatidylcholine-sterol O-acyltransferase activator activity
phospholipid binding
protein homodimerization activity
tau protein binding
very-low-density lipoprotein particle receptor binding
Gene Ontology Cellular Component:
blood microparticle
chylomicron
cytoplasm
dendrite
early endosome
endocytic vesicle lumen
endoplasmic reticulum
extracellular exosome
extracellular matrix
extracellular region
extracellular space
extracellular vesicle
Golgi apparatus
high-density lipoprotein particle
intermediate-density lipoprotein particle
low-density lipoprotein particle
membrane
neuronal cell body
nucleus
plasma membrane
very-low-density lipoprotein particle
Keywords:
3D-structure
Alzheimer disease
Amyloidosis
Cholesterol metabolism
Chylomicron
Complete proteome
Direct protein sequencing
Disease mutation
Glycation
Glycoprotein
HDL
Heparin-binding
Hyperlipidemia
Lipid metabolism
Lipid transport
Neurodegeneration
Oxidation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Secreted
Signal
Steroid metabolism
Sterol metabolism
Transport
VLDL
Interacts With:
P27958; Q16543; Q9BQ95; P00738; P01130; Q14114; P10636; Q53EL6; P50502; O75069

Publication

PubMed ID:
6325438 6327682 2987927 3243553 10520737 11042151 14702039 15489334 6897404 7068630 3283935 3947350 8346443 10452964 19838169 21269460 22905912 23234360 24275569 26091039 2063194 8756331 10850798 7833947 2760009 2556398 1674745 8488843 8287539 9176854 9360638 10432380 11095479 12864777 12966036 16094309 18077821 22028381 22481068 22949395