Names & Taxonomy
- Uniprot ID:
- P02462
- Entry Name:
- CO4A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(IV) chain [Cleaved into: Arresten]
- Gene Names:
- COL4A1
- Gene Names Primary:
- COL4A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1669
- Sequence:
- MGPRLSVWLLLLPAALLLHEEHSRAAAKGGCAGSGCGKCDCHGVKGQKGERGLPGLQGVIGFPGMQGPEGPQGPPGQKGDTGEPGLPGTKGTRGPPGASGYPGNPGLPGIPGQDGPPGPPGIPGCNGTKGERGPLGPPGLPGFAGNPGPPGLPGMKGDPGEILGHVPGMLLKGERGFPGIPGTPGPPGLPGLQGPVGPPGFTGPPGPPGPPGPPGEKGQMGLSFQGPKGDKGDQGVSGPPGVPGQAQVQEKGDFATKGEKGQKGEPGFQGMPGVGEKGEPGKPGPRGKPGKDGDKGEKGSPGFPGEPGYPGLIGRQGPQGEKGEAGPPGPPGIVIGTGPLGEKGERGYPGTPGPRGEPGPKGFPGLPGQPGPPGLPVPGQAGAPGFPGERGEKGDRGFPGTSLPGPSGRDGLPGPPGSPGPPGQPGYTNGIVECQPGPPGDQGPPGIPGQPGFIGEIGEKGQKGESCLICDIDGYRGPPGPQGPPGEIGFPGQPGAKGDRGLPGRDGVAGVPGPQGTPGLIGQPGAKGEPGEFYFDLRLKGDKGDPGFPGQPGMTGRAGSPGRDGHPGLPGPKGSPGSVGLKGERGPPGGVGFPGSRGDTGPPGPPGYGPAGPIGDKGQAGFPGGPGSPGLPGPKGEPGKIVPLPGPPGAEGLPGSPGFPGPQGDRGFPGTPGRPGLPGEKGAVGQPGIGFPGPPGPKGVDGLPGDMGPPGTPGRPGFNGLPGNPGVQGQKGEPGVGLPGLKGLPGLPGIPGTPGEKGSIGVPGVPGEHGAIGPPGLQGIRGEPGPPGLPGSVGSPGVPGIGPPGARGPPGGQGPPGLSGPPGIKGEKGFPGFPGLDMPGPKGDKGAQGLPGITGQSGLPGLPGQQGAPGIPGFPGSKGEMGVMGTPGQPGSPGPVGAPGLPGEKGDHGFPGSSGPRGDPGLKGDKGDVGLPGKPGSMDKVDMGSMKGQKGDQGEKGQIGPIGEKGSRGDPGTPGVPGKDGQAGQPGQPGPKGDPGISGTPGAPGLPGPKGSVGGMGLPGTPGEKGVPGIPGPQGSPGLPGDKGAKGEKGQAGPPGIGIPGLRGEKGDQGIAGFPGSPGEKGEKGSIGIPGMPGSPGLKGSPGSVGYPGSPGLPGEKGDKGLPGLDGIPGVKGEAGLPGTPGPTGPAGQKGEPGSDGIPGSAGEKGEPGLPGRGFPGFPGAKGDKGSKGEVGFPGLAGSPGIPGSKGEQGFMGPPGPQGQPGLPGSPGHATEGPKGDRGPQGQPGLPGLPGPMGPPGLPGIDGVKGDKGNPGWPGAPGVPGPKGDPGFQGMPGIGGSPGITGSKGDMGPPGVPGFQGPKGLPGLQGIKGDQGDQGVPGAKGLPGPPGPPGPYDIIKGEPGLPGPEGPPGLKGLQGLPGPKGQQGVTGLVGIPGPPGIPGFDGAPGQKGEMGPAGPTGPRGFPGPPGPDGLPGSMGPPGTPSVDHGFLVTRHSQTIDDPQCPSGTKILYHGYSLLYVQGNERAHGQDLGTAGSCLRKFSTMPFLFCNINNVCNFASRNDYSYWLSTPEPMPMSMAPITGENIRPFISRCAVCEAPAMVMAVHSQTIQIPPCPSGWSSLWIGYSFVMHTSAGAEGSGQALASPGSCLEEFRSAPFIECHGRGTCNYYANAYSFWLATIERSEMFKKPTPSTLKAGELRTHVSRCQVCMRRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix, basement membrane.
Function
- Function:
- Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.
- Gene Ontology Go:
- basement membrane
collagen type IV trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular matrix constituent conferring elasticity
extracellular matrix structural constituent
platelet-derived growth factor binding
axon guidance
basement membrane organization
blood vessel morphogenesis
brain development
cellular response to amino acid stimulus
collagen catabolic process
epithelial cell differentiation
extracellular matrix disassembly
extracellular matrix organization
neuromuscular junction development
patterning of blood vessels
receptor-mediated endocytosis
renal tubule morphogenesis
retinal blood vessel morphogenesis - Gene Ontology Biological Process:
- axon guidance
basement membrane organization
blood vessel morphogenesis
brain development
cellular response to amino acid stimulus
collagen catabolic process
epithelial cell differentiation
extracellular matrix disassembly
extracellular matrix organization
neuromuscular junction development
patterning of blood vessels
receptor-mediated endocytosis
renal tubule morphogenesis
retinal blood vessel morphogenesis - Gene Ontology Molecular Function:
- extracellular matrix constituent conferring elasticity
extracellular matrix structural constituent
platelet-derived growth factor binding - Gene Ontology Cellular Component:
- basement membrane
collagen type IV trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region - Keywords:
- 3D-structure
Alternative splicing
Angiogenesis
Basement membrane
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- P08572
Publication
- PubMed ID:
- 2701944 15057823 15489334 3311751 3182844 4043082 3691802 6434307 2581969 2582422 2844531 10811134 16481288 16151532 18775695 22522439 22574627 23394911 23225343 25228067 24628545 24275569 12011424 15905400 16107487 16598045 17696175 18160688 19729652 17379824 19194877 20818663 20385946 19477666 21527998