Names & Taxonomy
- Uniprot ID:
- P02461
- Entry Name:
- CO3A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(III) chain
- Gene Names:
- COL3A1
- Gene Names Primary:
- COL3A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1466
- Sequence:
- MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSVLCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPARNCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSSAEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMDQASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLPIVDIAPYDIGGPDQEFGVDVGPVCFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12.
- Cross Reference Drug Bank:
- DB00048
- Gene Ontology Go:
- collagen type III trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space
extracellular matrix structural constituent
integrin binding
metal ion binding
platelet-derived growth factor binding
aging
aorta smooth muscle tissue morphogenesis
axon guidance
cell-matrix adhesion
cellular response to amino acid stimulus
cerebral cortex development
collagen catabolic process
collagen fibril organization
digestive tract development
extracellular fibril organization
extracellular matrix disassembly
extracellular matrix organization
heart development
integrin-mediated signaling pathway
negative regulation of immune response
negative regulation of neuron migration
peptide cross-linking
platelet activation
positive regulation of Rho protein signal transduction
receptor-mediated endocytosis
regulation of immune response
response to cytokine
response to mechanical stimulus
response to radiation
skeletal system development
skin development
transforming growth factor beta receptor signaling pathway
wound healing - Gene Ontology Biological Process:
- aging
aorta smooth muscle tissue morphogenesis
axon guidance
cell-matrix adhesion
cellular response to amino acid stimulus
cerebral cortex development
collagen catabolic process
collagen fibril organization
digestive tract development
extracellular fibril organization
extracellular matrix disassembly
extracellular matrix organization
heart development
integrin-mediated signaling pathway
negative regulation of immune response
negative regulation of neuron migration
peptide cross-linking
platelet activation
positive regulation of Rho protein signal transduction
receptor-mediated endocytosis
regulation of immune response
response to cytokine
response to mechanical stimulus
response to radiation
skeletal system development
skin development
transforming growth factor beta receptor signaling pathway
wound healing - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
integrin binding
metal ion binding
platelet-derived growth factor binding - Gene Ontology Cellular Component:
- collagen type III trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space - Keywords:
- 3D-structure
Alternative splicing
Aortic aneurysm
Calcium
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Ehlers-Danlos syndrome
Extracellular matrix
Glycoprotein
Hydroxylation
Metal-binding
Polymorphism
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- O01949
Publication
- PubMed ID:
- 2764886 11566270 15815621 15489334 2777083 3405773 2780304 557335 8317500 7487954 7864881 687591 1672129 6246925 2145268 3357782 3211760 7016180 6096827 3754462 3858826 2579949 9101290 22905912 24275569 18805790 23001006 8514866 2235526 2243125 1370809 8411057 2492273 7749417 1352273 2808425 2349939 1895316 1357232 1496983 8098182 8255472 7912131 7833919 8019562 8680408 8884076 9147870 8664902 8990011 9036918 9452103 10819545 10923041 10706896 11168790 12694234 12786757 16959974 18272325