Names & Taxonomy
- Uniprot ID:
- P02452
- Entry Name:
- CO1A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Collagen alpha-1(I) chain (Alpha-1 type I collagen)
- Gene Names:
- COL1A1
- Gene Names Primary:
- COL1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1464
- Sequence:
- MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPTGPVGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPPSAGFDFSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKDKRHVWFGESMTDGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTVDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPVCFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix
Function
- Function:
- Type I collagen is a member of group I collagen (fibrillar forming collagen).
- Cross Reference Drug Bank:
- DB00048
- Gene Ontology Go:
- collagen type I trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space
Golgi apparatus
secretory granule
extracellular matrix structural constituent
identical protein binding
metal ion binding
platelet-derived growth factor binding
blood coagulation
blood vessel development
bone trabecula formation
cartilage development involved in endochondral bone morphogenesis
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to fibroblast growth factor stimulus
cellular response to fluoride
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
cellular response to tumor necrosis factor
cellular response to vitamin E
collagen biosynthetic process
collagen catabolic process
collagen fibril organization
embryonic skeletal system development
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
face morphogenesis
intramembranous ossification
leukocyte migration
negative regulation of cell-substrate adhesion
osteoblast differentiation
platelet activation
positive regulation of canonical Wnt signaling pathway
positive regulation of cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of transcription, DNA-templated
protein heterotrimerization
protein localization to nucleus
protein transport
receptor-mediated endocytosis
regulation of immune response
response to cAMP
response to corticosteroid
response to drug
response to estradiol
response to hydrogen peroxide
response to hyperoxia
response to peptide hormone
sensory perception of sound
skeletal system development
skin morphogenesis
tooth eruption
tooth mineralization
visual perception - Gene Ontology Biological Process:
- blood coagulation
blood vessel development
bone trabecula formation
cartilage development involved in endochondral bone morphogenesis
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to fibroblast growth factor stimulus
cellular response to fluoride
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
cellular response to tumor necrosis factor
cellular response to vitamin E
collagen biosynthetic process
collagen catabolic process
collagen fibril organization
embryonic skeletal system development
endochondral ossification
extracellular matrix disassembly
extracellular matrix organization
face morphogenesis
intramembranous ossification
leukocyte migration
negative regulation of cell-substrate adhesion
osteoblast differentiation
platelet activation
positive regulation of canonical Wnt signaling pathway
positive regulation of cell migration
positive regulation of epithelial to mesenchymal transition
positive regulation of transcription, DNA-templated
protein heterotrimerization
protein localization to nucleus
protein transport
receptor-mediated endocytosis
regulation of immune response
response to cAMP
response to corticosteroid
response to drug
response to estradiol
response to hydrogen peroxide
response to hyperoxia
response to peptide hormone
sensory perception of sound
skeletal system development
skin morphogenesis
tooth eruption
tooth mineralization
visual perception - Gene Ontology Molecular Function:
- extracellular matrix structural constituent
identical protein binding
metal ion binding
platelet-derived growth factor binding - Gene Ontology Cellular Component:
- collagen type I trimer
endoplasmic reticulum lumen
extracellular matrix
extracellular region
extracellular space
Golgi apparatus
secretory granule - Keywords:
- 3D-structure
Calcium
Chromosomal rearrangement
Collagen
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Dwarfism
Ehlers-Danlos syndrome
Extracellular matrix
Glycoprotein
Hydroxylation
Metal-binding
Osteogenesis imperfecta
Phosphoprotein
Polymorphism
Pyrrolidone carboxylic acid
Reference proteome
Repeat
Secreted
Signal - Interacts With:
- O01949
Publication
- PubMed ID:
- 9443882 15489334 2843432 3178743 6462220 2822714 2857713 3480516 2318855 2767050 5529814 2169412 4319110 2374517 6689127 6183642 2981843 3857621 2339700 7881420 8349697 3170557 3340531 2295701 1995349 2010058 9101290 1895312 14749390 22905912 24275569 3016737 3108247 3667599 3403550 3244312 2470760 2745420 2777764 2511192 2913053 2794057 2116413 2211725 2035536 1953667 2036375 2037280 1988452 1874719 1718984 1939261 1770532 1870989 1634225 1511982 1460047 1737847 1613761 8456808 8456809 8339541 7679635 8223589 8100209 7691343 8364588 8094076 8349698 7520724 8019571 7961597 7982948 8669434 8786074 8723681 8841196 9101304 9143923 9600458 10627137 9535665 10408781 10739762 8988177 12660034 15864348 16879195 16705691 16786509 16566045 16638323 17211858 17206620 17875077 18272325 18670065 18996919 21344539 24682174 25958000