Names & Taxonomy
- Uniprot ID:
- P01730
- Entry Name:
- CD4_HUMAN
- Status:
- reviewed
- Protein Names:
- T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
- Gene Names:
- CD4
- Gene Names Primary:
- CD4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 458
- Sequence:
- MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 (PubMed:2214026, PubMed:16331979, PubMed:9641677). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607).
- Cross Reference Drug Bank:
- DB00098
- Gene Ontology Go:
- early endosome
endoplasmic reticulum lumen
endoplasmic reticulum membrane
external side of plasma membrane
integral component of membrane
membrane raft
plasma membrane
T cell receptor complex
coreceptor activity
enzyme binding
extracellular matrix structural constituent
glycoprotein binding
MHC class II protein binding
protein homodimerization activity
protein kinase binding
receptor activity
transmembrane signaling receptor activity
virus receptor activity
zinc ion binding
adaptive immune response
cell surface receptor signaling pathway
cytokine production
defense response to Gram-negative bacterium
entry into host cell
enzyme linked receptor protein signaling pathway
helper T cell enhancement of adaptive immune response
immune response
induction by virus of host cell-cell fusion
innate immune response
maintenance of protein location in cell
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
positive regulation of interleukin-2 biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase activity
positive regulation of T cell proliferation
regulation of defense response to virus by virus
regulation of T cell activation
response to estradiol
response to vitamin D
signal transduction
T cell costimulation
T cell differentiation
T cell receptor signaling pathway
T cell selection
transmembrane receptor protein tyrosine kinase signaling pathway
viral process - Gene Ontology Biological Process:
- adaptive immune response
cell surface receptor signaling pathway
cytokine production
defense response to Gram-negative bacterium
entry into host cell
enzyme linked receptor protein signaling pathway
helper T cell enhancement of adaptive immune response
immune response
induction by virus of host cell-cell fusion
innate immune response
maintenance of protein location in cell
positive regulation of calcium ion transport into cytosol
positive regulation of calcium-mediated signaling
positive regulation of interleukin-2 biosynthetic process
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase activity
positive regulation of T cell proliferation
regulation of defense response to virus by virus
regulation of T cell activation
response to estradiol
response to vitamin D
signal transduction
T cell costimulation
T cell differentiation
T cell receptor signaling pathway
T cell selection
transmembrane receptor protein tyrosine kinase signaling pathway
viral process - Gene Ontology Molecular Function:
- coreceptor activity
enzyme binding
extracellular matrix structural constituent
glycoprotein binding
MHC class II protein binding
protein homodimerization activity
protein kinase binding
receptor activity
transmembrane signaling receptor activity
virus receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- early endosome
endoplasmic reticulum lumen
endoplasmic reticulum membrane
external side of plasma membrane
integral component of membrane
membrane raft
plasma membrane
T cell receptor complex - Keywords:
- 3D-structure
Adaptive immunity
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunity
Immunoglobulin domain
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P51681; P06239; P04150; P05919