Names & Taxonomy
- Uniprot ID:
- P01583
- Entry Name:
- IL1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
- Gene Names:
- IL1A IL1F1
- Gene Names Primary:
- IL1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 271
- Sequence:
- MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
Function
- Function:
- Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
- Cross Reference Drug Bank:
- DB06372
- Gene Ontology Go:
- cytosol
extracellular region
extracellular space
copper ion binding
cytokine activity
interleukin-1 receptor binding
apoptotic process
cell proliferation
cellular response to heat
connective tissue replacement involved in inflammatory response wound healing
cytokine-mediated signaling pathway
ectopic germ cell programmed cell death
extrinsic apoptotic signaling pathway in absence of ligand
fever generation
inflammatory response
inflammatory response to antigenic stimulus
negative regulation of cell proliferation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of angiogenesis
positive regulation of cytokine secretion
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-2 biosynthetic process
positive regulation of JNK cascade
positive regulation of mitotic nuclear division
positive regulation of protein secretion
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vascular endothelial growth factor production
response to copper ion - Gene Ontology Biological Process:
- apoptotic process
cell proliferation
cellular response to heat
connective tissue replacement involved in inflammatory response wound healing
cytokine-mediated signaling pathway
ectopic germ cell programmed cell death
extrinsic apoptotic signaling pathway in absence of ligand
fever generation
inflammatory response
inflammatory response to antigenic stimulus
negative regulation of cell proliferation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of angiogenesis
positive regulation of cytokine secretion
positive regulation of ERK1 and ERK2 cascade
positive regulation of gene expression
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-2 biosynthetic process
positive regulation of JNK cascade
positive regulation of mitotic nuclear division
positive regulation of protein secretion
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vascular endothelial growth factor production
response to copper ion - Gene Ontology Molecular Function:
- copper ion binding
cytokine activity
interleukin-1 receptor binding - Gene Ontology Cellular Component:
- cytosol
extracellular region
extracellular space - Keywords:
- 3D-structure
Complete proteome
Cytokine
Direct protein sequencing
Glycoprotein
Inflammatory response
Lipoprotein
Mitogen
Myristate
Phosphoprotein
Polymorphism
Pyrogen
Reference proteome
Secreted - Interacts With:
- P29466