Names & Taxonomy
- Uniprot ID:
- P01574
- Entry Name:
- IFNB_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon beta (IFN-beta) (Fibroblast interferon)
- Gene Names:
- IFNB1 IFB IFNB
- Gene Names Primary:
- IFNB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 187
- Sequence:
- MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Has antiviral, antibacterial and anticancer activities.
- Gene Ontology Go:
- extracellular region
extracellular space
chloramphenicol O-acetyltransferase activity
cytokine activity
type I interferon receptor binding
adaptive immune response
B cell activation involved in immune response
B cell differentiation
B cell proliferation
blood coagulation
cell surface receptor signaling pathway
cellular response to dexamethasone stimulus
cellular response to exogenous dsRNA
cellular response to interferon-beta
cellular response to virus
cytokine-mediated signaling pathway
defense response to bacterium
defense response to virus
humoral immune response
innate immune response
natural killer cell activation
natural killer cell activation involved in immune response
negative regulation of T cell differentiation
negative regulation of T-helper 2 cell cytokine production
negative regulation of viral genome replication
positive regulation of apoptotic signaling pathway
positive regulation of innate immune response
positive regulation of peptidyl-serine phosphorylation of STAT protein
positive regulation of transcription from RNA polymerase II promoter
regulation of MHC class I biosynthetic process
regulation of type I interferon-mediated signaling pathway
response to exogenous dsRNA
response to virus
T cell activation involved in immune response
type I interferon signaling pathway - Gene Ontology Biological Process:
- adaptive immune response
B cell activation involved in immune response
B cell differentiation
B cell proliferation
blood coagulation
cell surface receptor signaling pathway
cellular response to dexamethasone stimulus
cellular response to exogenous dsRNA
cellular response to interferon-beta
cellular response to virus
cytokine-mediated signaling pathway
defense response to bacterium
defense response to virus
humoral immune response
innate immune response
natural killer cell activation
natural killer cell activation involved in immune response
negative regulation of T cell differentiation
negative regulation of T-helper 2 cell cytokine production
negative regulation of viral genome replication
positive regulation of apoptotic signaling pathway
positive regulation of innate immune response
positive regulation of peptidyl-serine phosphorylation of STAT protein
positive regulation of transcription from RNA polymerase II promoter
regulation of MHC class I biosynthetic process
regulation of type I interferon-mediated signaling pathway
response to exogenous dsRNA
response to virus
T cell activation involved in immune response
type I interferon signaling pathway - Gene Ontology Molecular Function:
- chloramphenicol O-acetyltransferase activity
cytokine activity
type I interferon receptor binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space - Keywords:
- 3D-structure
Antiviral defense
Complete proteome
Cytokine
Disulfide bond
Glycoprotein
Pharmaceutical
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal