Names & Taxonomy

Uniprot ID:
P01303
Entry Name:
NPY_HUMAN
Status:
reviewed
Protein Names:
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
Gene Names:
NPY
Gene Names Primary:
NPY
Organism:
Homo sapiens (Human)

Structure

Length:
97
Sequence:
MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Gene Ontology Go:
cell
extracellular region
extracellular space
Golgi apparatus
calcium channel regulator activity
G-protein coupled receptor activity
G-protein coupled receptor binding
neuropeptide hormone activity
receptor binding
adult feeding behavior
antibacterial humoral response
antifungal humoral response
behavior
blood circulation
calcium ion transport
cell proliferation
central nervous system neuron development
cerebral cortex development
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
digestion
feeding behavior
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
innate immune response
movement of cell or subcellular component
neuron projection development
neuropeptide signaling pathway
positive regulation of appetite
regulation of appetite
regulation of blood pressure
response to yeast
synaptic transmission
Gene Ontology Biological Process:
adult feeding behavior
antibacterial humoral response
antifungal humoral response
behavior
blood circulation
calcium ion transport
cell proliferation
central nervous system neuron development
cerebral cortex development
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
digestion
feeding behavior
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
innate immune response
movement of cell or subcellular component
neuron projection development
neuropeptide signaling pathway
positive regulation of appetite
regulation of appetite
regulation of blood pressure
response to yeast
synaptic transmission
Gene Ontology Molecular Function:
calcium channel regulator activity
G-protein coupled receptor activity
G-protein coupled receptor binding
neuropeptide hormone activity
receptor binding
Gene Ontology Cellular Component:
cell
extracellular region
extracellular space
Golgi apparatus
Keywords:
3D-structure
Amidation
Cleavage on pair of basic residues
Complete proteome
Neuropeptide
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal

Publication

PubMed ID:
6589611 2427515 3753985 12853948 15489334 3839058 21314817 24275569 1425680 9008359 10561544