Names & Taxonomy

Uniprot ID:
P01138
Entry Name:
NGF_HUMAN
Status:
reviewed
Protein Names:
Beta-nerve growth factor (Beta-NGF)
Gene Names:
NGF NGFB
Gene Names Primary:
NGF
Organism:
Homo sapiens (Human)

Structure

Length:
241
Sequence:
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRRA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Cross Reference Drug Bank:
DB01407
Gene Ontology Go:
cytoplasmic, membrane-bounded vesicle
endosome
extracellular region
Golgi lumen
growth factor activity
metalloendopeptidase inhibitor activity
nerve growth factor receptor binding
activation of MAPKK activity
activation of phospholipase C activity
apoptotic signaling pathway
cell-cell signaling
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of apoptotic process
negative regulation of cell cycle
negative regulation of endopeptidase activity
negative regulation of neuron apoptotic process
nerve growth factor processing
neuron projection morphogenesis
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of apoptotic process
positive regulation of axonogenesis
positive regulation of gene expression
Ras protein signal transduction
regulation of axonogenesis
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron differentiation
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Biological Process:
activation of MAPKK activity
activation of phospholipase C activity
apoptotic signaling pathway
cell-cell signaling
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of apoptotic process
negative regulation of cell cycle
negative regulation of endopeptidase activity
negative regulation of neuron apoptotic process
nerve growth factor processing
neuron projection morphogenesis
neurotrophin TRK receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of apoptotic process
positive regulation of axonogenesis
positive regulation of gene expression
Ras protein signal transduction
regulation of axonogenesis
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of neuron differentiation
small GTPase mediated signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
Gene Ontology Molecular Function:
growth factor activity
metalloendopeptidase inhibitor activity
nerve growth factor receptor binding
Gene Ontology Cellular Component:
cytoplasmic, membrane-bounded vesicle
endosome
extracellular region
Golgi lumen
Keywords:
3D-structure
Cleavage on pair of basic residues
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Growth factor
Metalloenzyme inhibitor
Metalloprotease inhibitor
Neurodegeneration
Neuropathy
Polymorphism
Protease inhibitor
Reference proteome
Secreted
Signal
Interacts With:
P08138; P07174; P04629; Q99523

Publication

PubMed ID:
6688123 6327169 2374737 10322959 15014171 16710414 15489334 2025430 1849459 20164177 10490030 10391209 14976160 20978020 22302274