Names & Taxonomy
- Uniprot ID:
- P01133
- Entry Name:
- EGF_HUMAN
- Status:
- reviewed
- Protein Names:
- Pro-epidermal growth factor (EGF) [Cleaved into: Epidermal growth factor (Urogastrone)]
- Gene Names:
- EGF
- Gene Names Primary:
- EGF
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1207
- Sequence:
- MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein.
Function
- Function:
- EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (PubMed:10964941).
- Cross Reference Drug Bank:
- DB00364
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
integral component of membrane
lysosomal membrane
plasma membrane
platelet alpha granule lumen
receptor complex
calcium ion binding
epidermal growth factor receptor binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
Wnt-activated receptor activity
Wnt-protein binding
activation of MAPK activity
activation of MAPKK activity
activation of transmembrane receptor protein tyrosine kinase activity
angiogenesis
axon guidance
blood coagulation
branching morphogenesis of an epithelial tube
canonical Wnt signaling pathway
DNA replication
epidermal growth factor receptor signaling pathway
ERK1 and ERK2 cascade
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
mammary gland alveolus development
MAPK cascade
negative regulation of cholesterol efflux
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of secretion
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet activation
platelet degranulation
positive regulation of catenin import into nucleus
positive regulation of cell proliferation
positive regulation of cerebellar granule cell precursor proliferation
positive regulation of DNA binding
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of hyaluronan biosynthetic process
positive regulation of MAP kinase activity
positive regulation of mitotic nuclear division
positive regulation of peptidyl-threonine phosphorylation
positive regulation of phosphorylation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
Ras protein signal transduction
regulation of calcium ion import
regulation of protein localization to cell surface
signal transduction
small GTPase mediated signal transduction
STAT protein import into nucleus
vascular endothelial growth factor receptor signaling pathway
Wnt signaling pathway involved in dorsal/ventral axis specification - Gene Ontology Biological Process:
- activation of MAPK activity
activation of MAPKK activity
activation of transmembrane receptor protein tyrosine kinase activity
angiogenesis
axon guidance
blood coagulation
branching morphogenesis of an epithelial tube
canonical Wnt signaling pathway
DNA replication
epidermal growth factor receptor signaling pathway
ERK1 and ERK2 cascade
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
insulin receptor signaling pathway
mammary gland alveolus development
MAPK cascade
negative regulation of cholesterol efflux
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of secretion
neurotrophin TRK receptor signaling pathway
peptidyl-tyrosine phosphorylation
phosphatidylinositol-mediated signaling
platelet activation
platelet degranulation
positive regulation of catenin import into nucleus
positive regulation of cell proliferation
positive regulation of cerebellar granule cell precursor proliferation
positive regulation of DNA binding
positive regulation of epidermal growth factor-activated receptor activity
positive regulation of hyaluronan biosynthetic process
positive regulation of MAP kinase activity
positive regulation of mitotic nuclear division
positive regulation of peptidyl-threonine phosphorylation
positive regulation of phosphorylation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
Ras protein signal transduction
regulation of calcium ion import
regulation of protein localization to cell surface
signal transduction
small GTPase mediated signal transduction
STAT protein import into nucleus
vascular endothelial growth factor receptor signaling pathway
Wnt signaling pathway involved in dorsal/ventral axis specification - Gene Ontology Molecular Function:
- calcium ion binding
epidermal growth factor receptor binding
growth factor activity
transmembrane receptor protein tyrosine kinase activator activity
Wnt-activated receptor activity
Wnt-protein binding - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
integral component of membrane
lysosomal membrane
plasma membrane
platelet alpha granule lumen
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Membrane
Polymorphism
Primary hypomagnesemia
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix - Interacts With:
- P00533; Q01279