Names & Taxonomy
- Uniprot ID:
- P01106
- Entry Name:
- MYC_HUMAN
- Status:
- reviewed
- Protein Names:
- Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
- Gene Names:
- MYC BHLHE39
- Gene Names Primary:
- MYC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 439
- Sequence:
- MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleoplasm
Function
- Function:
- Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CACTG-3'. Activates the transcription of growth-related genes.
- Cross Reference Drug Bank:
- DB08813
- Gene Ontology Go:
- cytosol
nucleolus
nucleoplasm
nucleus
protein complex
DNA binding
E-box binding
protein complex binding
repressing transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
branching involved in ureteric bud morphogenesis
canonical Wnt signaling pathway
cell cycle arrest
cellular iron ion homeostasis
cellular response to DNA damage stimulus
cellular response to drug
cellular response to UV
chromatin remodeling
chromosome organization
energy reserve metabolic process
fibroblast apoptotic process
gene expression
MAPK cascade
negative regulation of apoptotic process
negative regulation of cell division
negative regulation of fibroblast proliferation
negative regulation of monocyte differentiation
negative regulation of stress-activated MAPK cascade
negative regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
oxygen transport
positive regulation of cell proliferation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of DNA biosynthetic process
positive regulation of epithelial cell proliferation
positive regulation of fibroblast proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of metanephric cap mesenchymal cell proliferation
positive regulation of response to DNA damage stimulus
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of gene expression
regulation of telomere maintenance
response to drug
response to gamma radiation
response to growth factor
transcription initiation from RNA polymerase II promoter
transcription, DNA-templated
transforming growth factor beta receptor signaling pathway - Gene Ontology Biological Process:
- branching involved in ureteric bud morphogenesis
canonical Wnt signaling pathway
cell cycle arrest
cellular iron ion homeostasis
cellular response to DNA damage stimulus
cellular response to drug
cellular response to UV
chromatin remodeling
chromosome organization
energy reserve metabolic process
fibroblast apoptotic process
gene expression
MAPK cascade
negative regulation of apoptotic process
negative regulation of cell division
negative regulation of fibroblast proliferation
negative regulation of monocyte differentiation
negative regulation of stress-activated MAPK cascade
negative regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
oxygen transport
positive regulation of cell proliferation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of DNA biosynthetic process
positive regulation of epithelial cell proliferation
positive regulation of fibroblast proliferation
positive regulation of mesenchymal cell proliferation
positive regulation of metanephric cap mesenchymal cell proliferation
positive regulation of response to DNA damage stimulus
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of gene expression
regulation of telomere maintenance
response to drug
response to gamma radiation
response to growth factor
transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway - Gene Ontology Molecular Function:
- DNA binding
E-box binding
protein complex binding
repressing transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
transcription factor binding - Gene Ontology Cellular Component:
- cytosol
nucleolus
nucleoplasm
nucleus
protein complex - Keywords:
- 3D-structure
Acetylation
Activator
Alternative splicing
Chromosomal rearrangement
Complete proteome
DNA-binding
Glycoprotein
Nucleus
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- P03070; O15169; O00499-10; O00499-11; Q15059; Q8N163; P11802; Q86XR8; Q14839; O15111; P03129; P04020; P06788; P03204; Q15029; Q969H0; Q8N3Y1; Q92769; O15379; Q9Y6K9; Q8TCG1; P61244; P52164; P33993; O75928; P62913; O75182; Q62141; Q96EB6; Q8N6T7; Q13309; Q8TAD8; P08047; P11387; Q9Y4A5; P0CG48; P17480; Q13105
Publication
- PubMed ID:
- 6414718 6321164 6298632 6304538 6419122 6304729 6547209 6714223 8444346 14702039 16421571 15489334 3540591 2166998 1597196 8220424 8386367 7642555 9315742 15103331 16126174 15723054 15674325 17081983 18035408 17873522 17311883 17308053 17558397 18669648 19413330 19608861 20713526 19966300 20551172 20068231 21406692 22307329 9680483 2069907