Names & Taxonomy

Uniprot ID:
P01024
Entry Name:
CO3_HUMAN
Status:
reviewed
Protein Names:
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene Names:
C3 CPAMD1
Gene Names Primary:
C3
Organism:
Homo sapiens (Human)

Structure

Length:
1663
Sequence:
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Cross Reference Drug Bank:
DB00028
Gene Ontology Go:
blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane
C5L2 anaphylatoxin chemotactic receptor binding
cofactor binding
endopeptidase inhibitor activity
lipid binding
receptor binding
blood coagulation
complement activation
complement activation, alternative pathway
complement activation, classical pathway
fatty acid metabolic process
G-protein coupled receptor signaling pathway
immune response
inflammatory response
innate immune response
positive regulation of activation of membrane attack complex
positive regulation of angiogenesis
positive regulation of apoptotic cell clearance
positive regulation of developmental growth
positive regulation of ERK1 and ERK2 cascade
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of glucose transport
positive regulation of lipid storage
positive regulation of protein phosphorylation
positive regulation of type IIa hypersensitivity
positive regulation of vascular endothelial growth factor production
regulation of complement activation
regulation of immune response
regulation of triglyceride biosynthetic process
response to estradiol
response to glucocorticoid
response to magnesium ion
response to progesterone
signal transduction
tolerance induction
Gene Ontology Biological Process:
blood coagulation
complement activation
complement activation, alternative pathway
complement activation, classical pathway
fatty acid metabolic process
G-protein coupled receptor signaling pathway
immune response
inflammatory response
innate immune response
positive regulation of activation of membrane attack complex
positive regulation of angiogenesis
positive regulation of apoptotic cell clearance
positive regulation of developmental growth
positive regulation of ERK1 and ERK2 cascade
positive regulation of glucose transport
positive regulation of G-protein coupled receptor protein signaling pathway
positive regulation of lipid storage
positive regulation of protein phosphorylation
positive regulation of type IIa hypersensitivity
positive regulation of vascular endothelial growth factor production
regulation of complement activation
regulation of immune response
regulation of triglyceride biosynthetic process
response to estradiol
response to glucocorticoid
response to magnesium ion
response to progesterone
signal transduction
tolerance induction
Gene Ontology Molecular Function:
C5L2 anaphylatoxin chemotactic receptor binding
cofactor binding
endopeptidase inhibitor activity
lipid binding
receptor binding
Gene Ontology Cellular Component:
blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane
Keywords:
3D-structure
Age-related macular degeneration
Cleavage on pair of basic residues
Complement alternate pathway
Complement pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Fatty acid metabolism
Glycoprotein
Hemolytic uremic syndrome
Immunity
Inflammatory response
Innate immunity
Lipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Secreted
Signal
Thioester bond
Interacts With:
P08603; Q9Y279-1; Q9Y279-2

Publication

PubMed ID:
2579379 15489334 8376604 1238393 7539791 6175959 3279119 2849025 2909530 1577777 8416818 9059512 9555951 10432298 11773063 12540846 12754519 14760718 15809665 15833747 16335952 16302015 16333141 16263699 18805911 19159218 19615750 20083651 20951140 19913840 21269460 24275569 26091039 3260670 9596584 11387479 15713468 16177781 17051160 17051150 17684013 17351618 21055811 21527715 2473125 2584723 1976733 7961791 17634448 18796626 20513133 22028381 21555552 24036952