Names & Taxonomy
- Uniprot ID:
- P00751
- Entry Name:
- CFAB_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement factor B (EC 3.4.21.47) (C3/C5 convertase) (Glycine-rich beta glycoprotein) (GBG) (PBF2) (Properdin factor B) [Cleaved into: Complement factor B Ba fragment; Complement factor B Bb fragment]
- Gene Names:
- CFB BF BFD
- Gene Names Primary:
- CFB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 764
- Sequence:
- MGSNLSPQLCLMPFILGLLSGGVTTTPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
- Catalytic Activity:
- Cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to yield C5a and C5b.
- Active Site:
- ACT_SITE 526 526 Charge relay system.; ACT_SITE 576 576 Charge relay system.; ACT_SITE 699 699 Charge relay system.
- Gene Ontology Go:
- blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane
complement binding
serine-type endopeptidase activity
complement activation
complement activation, alternative pathway
innate immune response
regulation of complement activation - Gene Ontology Biological Process:
- complement activation
complement activation, alternative pathway
innate immune response
regulation of complement activation - Gene Ontology Molecular Function:
- complement binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- blood microparticle
extracellular exosome
extracellular region
extracellular space
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complement alternate pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein
Hemolytic uremic syndrome
Hydrolase
Immunity
Innate immunity
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi
Zymogen