Names & Taxonomy
- Uniprot ID:
- P00750
- Entry Name:
- TPA_HUMAN
- Status:
- reviewed
- Protein Names:
- Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]
- Gene Names:
- PLAT
- Gene Names Primary:
- PLAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 562
- Sequence:
- MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
- Catalytic Activity:
- Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by SERPINA5.
- Active Site:
- ACT_SITE 357 357 Charge relay system.; ACT_SITE 406 406 Charge relay system.; ACT_SITE 513 513 Charge relay system.
- Cross Reference Drug Bank:
- DB00513 DB01050 DB01088 DB00013
- Gene Ontology Go:
- apical part of cell
cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
secretory granule
glycoprotein binding
phosphoprotein binding
receptor binding
serine-type endopeptidase activity
blood coagulation
cellular protein modification process
fibrinolysis
negative regulation of proteolysis
plasminogen activation
platelet-derived growth factor receptor signaling pathway
proteolysis
response to hypoxia
smooth muscle cell migration - Gene Ontology Biological Process:
- blood coagulation
cellular protein modification process
fibrinolysis
negative regulation of proteolysis
plasminogen activation
platelet-derived growth factor receptor signaling pathway
proteolysis
response to hypoxia
smooth muscle cell migration - Gene Ontology Molecular Function:
- glycoprotein binding
phosphoprotein binding
receptor binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- apical part of cell
cell surface
cytoplasm
extracellular exosome
extracellular region
extracellular space
secretory granule - Keywords:
- 3D-structure
Alternative splicing
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Hydrolase
Kringle
Pharmaceutical
Plasminogen activation
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen