Names & Taxonomy
- Uniprot ID:
- P00748
- Entry Name:
- FA12_HUMAN
- Status:
- reviewed
- Protein Names:
- Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
- Gene Names:
- F12
- Gene Names Primary:
- F12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 615
- Sequence:
- MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHKCTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
- Catalytic Activity:
- Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
- Active Site:
- ACT_SITE 412 412 Charge relay system.
- Cross Reference Drug Bank:
- DB06689
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
plasma membrane
misfolded protein binding
serine-type endopeptidase activity
blood coagulation
blood coagulation, intrinsic pathway
Factor XII activation
fibrinolysis
innate immune response
plasma kallikrein-kinin cascade
positive regulation of blood coagulation
positive regulation of fibrinolysis
positive regulation of plasminogen activation
protein autoprocessing
protein processing
response to misfolded protein
zymogen activation - Gene Ontology Biological Process:
- blood coagulation
blood coagulation, intrinsic pathway
Factor XII activation
fibrinolysis
innate immune response
plasma kallikrein-kinin cascade
positive regulation of blood coagulation
positive regulation of fibrinolysis
positive regulation of plasminogen activation
protein autoprocessing
protein processing
response to misfolded protein
zymogen activation - Gene Ontology Molecular Function:
- misfolded protein binding
serine-type endopeptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
plasma membrane - Keywords:
- 3D-structure
Blood coagulation
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Fibrinolysis
Glycoprotein
Hemostasis
Hydrolase
Kringle
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Zymogen - Interacts With:
- Q07021