Names & Taxonomy
- Uniprot ID:
- P00746
- Entry Name:
- CFAD_HUMAN
- Status:
- reviewed
- Protein Names:
- Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D)
- Gene Names:
- CFD DF PFD
- Gene Names Primary:
- CFD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 253
- Sequence:
- MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
- Catalytic Activity:
- Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
- Active Site:
- ACT_SITE 66 66 Charge relay system.; ACT_SITE 114 114 Charge relay system.; ACT_SITE 208 208 Charge relay system.
- Gene Ontology Go:
- extracellular exosome
extracellular region
extracellular space
platelet alpha granule lumen
serine-type endopeptidase activity
serine-type peptidase activity
blood coagulation
complement activation
complement activation, alternative pathway
innate immune response
platelet activation
platelet degranulation
proteolysis - Gene Ontology Biological Process:
- blood coagulation
complement activation
complement activation, alternative pathway
innate immune response
platelet activation
platelet degranulation
proteolysis - Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- extracellular exosome
extracellular region
extracellular space
platelet alpha granule lumen - Keywords:
- 3D-structure
Complement alternate pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Hydrolase
Immunity
Innate immunity
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen