Names & Taxonomy

Uniprot ID:
P00746
Entry Name:
CFAD_HUMAN
Status:
reviewed
Protein Names:
Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D)
Gene Names:
CFD DF PFD
Gene Names Primary:
CFD
Organism:
Homo sapiens (Human)

Structure

Length:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
Catalytic Activity:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
Active Site:
ACT_SITE 66 66 Charge relay system.; ACT_SITE 114 114 Charge relay system.; ACT_SITE 208 208 Charge relay system.
Gene Ontology Go:
extracellular exosome
extracellular region
extracellular space
platelet alpha granule lumen
serine-type endopeptidase activity
serine-type peptidase activity
blood coagulation
complement activation
complement activation, alternative pathway
innate immune response
platelet activation
platelet degranulation
proteolysis
Gene Ontology Biological Process:
blood coagulation
complement activation
complement activation, alternative pathway
innate immune response
platelet activation
platelet degranulation
proteolysis
Gene Ontology Molecular Function:
serine-type endopeptidase activity
serine-type peptidase activity
Gene Ontology Cellular Component:
extracellular exosome
extracellular region
extracellular space
platelet alpha granule lumen
Keywords:
3D-structure
Complement alternate pathway
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Hydrolase
Immunity
Innate immunity
Polymorphism
Protease
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Publication

PubMed ID:
14702039 15489334 1374388 6383466 6363133 6987665 6776531 6821372 22905912 8289289 7592653 16527897