Names & Taxonomy

Uniprot ID:
P00740
Entry Name:
FA9_HUMAN
Status:
reviewed
Protein Names:
Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
Gene Names:
F9
Gene Names Primary:
F9
Organism:
Homo sapiens (Human)

Structure

Length:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
Catalytic Activity:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Active Site:
ACT_SITE 267 267 Charge relay system.
Cross Reference Drug Bank:
DB00025 DB00170
Gene Ontology Go:
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
calcium ion binding
endopeptidase activity
serine-type endopeptidase activity
blood coagulation
blood coagulation, extrinsic pathway
blood coagulation, intrinsic pathway
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
post-translational protein modification
proteolysis
signal peptide processing
zymogen activation
Gene Ontology Biological Process:
blood coagulation
blood coagulation, extrinsic pathway
blood coagulation, intrinsic pathway
cellular protein metabolic process
ER to Golgi vesicle-mediated transport
peptidyl-glutamic acid carboxylation
post-translational protein modification
proteolysis
signal peptide processing
zymogen activation
Gene Ontology Molecular Function:
calcium ion binding
endopeptidase activity
serine-type endopeptidase activity
Gene Ontology Cellular Component:
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
Keywords:
3D-structure
Alternative splicing
Blood coagulation
Calcium
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
EGF-like domain
Gamma-carboxyglutamic acid
Glycoprotein
Hemophilia
Hemostasis
Hydrolase
Hydroxylation
Magnesium
Metal-binding
Pharmaceutical
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sulfation
Thrombophilia
Zymogen

Publication

PubMed ID:
6959130 6687940 6329734 2994716 3857619 14702039 15772651 15489334 8295821 6089357 2592373 9169594 3340835 8236150 6688526 659613 6425296 2511201 2129367 1730085 1517205 8172892 11133752 12444082 21949356 25456591 24275569 7713897 7547952 8663165 9047312 1854745 1304885 7606779 10467148 14722079 20004170 20121198 20121197 20080729 2743975 1634040 8392713 6603618 3009023 3790720 3401602 3243764 2713493 2714791 2773937 2775660 2753873 2738071 2472424 2339358 2372509 2162822 1958666 1902289 1346975 1615485 8257988 8076946 8199596 7981722 8680410 8833911 9222764 9590153 9452115 9600455 10698280 10094553 10391209 11122099 12588353 12604421 19846852 25470321 25251685