Names & Taxonomy
- Uniprot ID:
- P00505
- Entry Name:
- AATM_HUMAN
- Status:
- reviewed
- Protein Names:
- Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)
- Gene Names:
- GOT2
- Gene Names Primary:
- GOT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 430
- Sequence:
- MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKMNLGVGAYRDDNGKPYVLPSVRKAEAQIAAKNLDKEYLPIGGLAEFCKASAELALGENSEVLKSGRFVTVQTISGTGALRIGASFLQRFFKFSRDVFLPKPTWGNHTPIFRDAGMQLQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVKKRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMVCKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGMRTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVTSSNVGYLAHAIHQVTK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Function:
- Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
- Catalytic Activity:
- L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.; L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00128
- Gene Ontology Go:
- cell surface
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
myelin sheath
perikaryon
plasma membrane
protein complex
amino acid binding
identical protein binding
kynurenine-oxoglutarate transaminase activity
L-aspartate:2-oxoglutarate aminotransferase activity
L-phenylalanine:2-oxoglutarate aminotransferase activity
phospholipid binding
poly(A) RNA binding
pyridoxal phosphate binding
2-oxoglutarate metabolic process
4-hydroxyproline catabolic process
aspartate biosynthetic process
aspartate catabolic process
aspartate metabolic process
carbohydrate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
fatty acid transport
gluconeogenesis
glucose metabolic process
glutamate catabolic process to 2-oxoglutarate
glutamate catabolic process to aspartate
glutamate metabolic process
oxaloacetate metabolic process
response to ethanol
small molecule metabolic process - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
4-hydroxyproline catabolic process
aspartate biosynthetic process
aspartate catabolic process
aspartate metabolic process
carbohydrate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
fatty acid transport
gluconeogenesis
glucose metabolic process
glutamate catabolic process to 2-oxoglutarate
glutamate catabolic process to aspartate
glutamate metabolic process
oxaloacetate metabolic process
response to ethanol
small molecule metabolic process - Gene Ontology Molecular Function:
- amino acid binding
identical protein binding
kynurenine-oxoglutarate transaminase activity
L-aspartate:2-oxoglutarate aminotransferase activity
L-phenylalanine:2-oxoglutarate aminotransferase activity
phospholipid binding
poly(A) RNA binding
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- cell surface
extracellular exosome
mitochondrial inner membrane
mitochondrial matrix
mitochondrion
myelin sheath
perikaryon
plasma membrane
protein complex - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aminotransferase
Cell membrane
Complete proteome
Direct protein sequencing
Lipid transport
Membrane
Mitochondrion
Nitration
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase
Transit peptide
Transport