Names & Taxonomy

Uniprot ID:
P00491
Entry Name:
PNPH_HUMAN
Status:
reviewed
Protein Names:
Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)
Gene Names:
PNP NP
Gene Names Primary:
PNP
Organism:
Homo sapiens (Human)

Structure

Length:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Pathway:
Purine metabolism; purine nucleoside salvage.
Catalytic Activity:
Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.
Cross Reference Drug Bank:
DB00242 DB00900
Gene Ontology Go:
cytoplasm
cytoskeleton
cytosol
extracellular exosome
intracellular
nucleus
drug binding
nucleoside binding
phosphate ion binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
immune response
inosine catabolic process
interleukin-2 secretion
NAD biosynthesis via nicotinamide riboside salvage pathway
nicotinamide riboside catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
positive regulation of alpha-beta T cell differentiation
positive regulation of T cell proliferation
purine nucleobase metabolic process
purine nucleotide catabolic process
purine-containing compound salvage
response to drug
small molecule metabolic process
urate biosynthetic process
Gene Ontology Biological Process:
immune response
inosine catabolic process
interleukin-2 secretion
NAD biosynthesis via nicotinamide riboside salvage pathway
nicotinamide riboside catabolic process
nucleobase-containing compound metabolic process
nucleobase-containing small molecule metabolic process
positive regulation of alpha-beta T cell differentiation
positive regulation of T cell proliferation
purine-containing compound salvage
purine nucleobase metabolic process
purine nucleotide catabolic process
response to drug
small molecule metabolic process
urate biosynthetic process
Gene Ontology Molecular Function:
drug binding
nucleoside binding
phosphate ion binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
Gene Ontology Cellular Component:
cytoplasm
cytoskeleton
cytosol
extracellular exosome
intracellular
nucleus
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Glycosyltransferase
Polymorphism
Reference proteome
Transferase

Publication

PubMed ID:
6087295 3029074 12928150 14702039 15489334 19413330 21269460 22223895 22509282 24275569 25944712 2104852 1384322 8931706