Names & Taxonomy
- Uniprot ID:
- P00488
- Entry Name:
- F13A_HUMAN
- Status:
- reviewed
- Protein Names:
- Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)
- Gene Names:
- F13A1 F13A
- Gene Names Primary:
- F13A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 732
- Sequence:
- MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Secreted
Function
- Function:
- Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 315 315
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- blood microparticle
extracellular region
platelet alpha granule lumen
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
blood coagulation
peptide cross-linking
platelet activation
platelet degranulation - Gene Ontology Biological Process:
- blood coagulation
peptide cross-linking
platelet activation
platelet degranulation - Gene Ontology Molecular Function:
- metal ion binding
protein-glutamine gamma-glutamyltransferase activity - Gene Ontology Cellular Component:
- blood microparticle
extracellular region
platelet alpha granule lumen - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Blood coagulation
Calcium
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Glycoprotein
Hemostasis
Metal-binding
Polymorphism
Reference proteome
Secreted
Transferase
Zymogen